D. C. Ghislaine Mayer

TL;DR: The current state of knowledge about the receptor-ligand interactions that mediate merozoite invasion of erythrocytes is reviewed.

TL;DR: The interest in BAEBL's reduced binding to Gerbich erythrocytes derives from the high frequency of theGerbich phenotype in some regions of Papua New Guinea where P. falciparum is hyperendemic.

TL;DR: Evidence is provided that glycophorin B is a receptor for the P. falciparum protein EBL-1, a member of the Duffy-binding-like erythrocyte-binding protein (DBL-EBP) receptor family, and Interestingly, the Efe pygmies of the Ituri forest in the Democratic Republic of the Congo have the highest gene frequency of glycoph orin B-null in the world, raising the possibility that the DBL

TL;DR: The results suggest that P. falciparum has evolved multiple invasion pathways dependent on polymorphisms in the BAEBL ligand, which is similar to other parasite ligand species.

TL;DR: Six P. falciparum DBL ligands JESEBL and BAEBL can recognize multiple receptors on the erythrocyte surface and may have been successful in endemic areas because it has mutated the ligands of the DBL family to create multiple pathways of invasion, thus making selection of refractory ERYthrocytes unlikely.