J
Juraj Kabat
Researcher at National Institutes of Health
Publications - 72
Citations - 4246
Juraj Kabat is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 26, co-authored 54 publications receiving 3367 citations.
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Journal ArticleDOI
Activation of Autophagy by Inflammatory Signals Limits IL-1β Production by Targeting Ubiquitinated Inflammasomes for Destruction
Chong-Shan Shi,Kevin Shenderov,Ning Na Huang,Juraj Kabat,Mones Abu-Asab,Katherine A. Fitzgerald,Alan Sher,John H. Kehrl +7 more
TL;DR: It is shown that the induction of AIM2 or NLRP3 inflammasomes in macrophages triggered activation of the G protein RalB and autophagosome formation, which indicates that autophagy accompaniesinflammasome activation to temper inflammation by eliminating active inflammaomes.
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Histo-Cytometry: A Method for Highly Multiplex Quantitative Tissue Imaging Analysis Applied to Dendritic Cell Subset Microanatomy in Lymph Nodes
TL;DR: Histo-cytometry is employed to describe the spatial segregation of resident and migratory dendritic cell subsets into specialized microanatomical domains, suggesting an unexpected LN demarcation into discrete functional compartments.
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Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells.
Francisco Borrego,Juraj Kabat,Dae-Ki Kim,Louis D. Lieto,Kerima Maasho,José Jesús Delgado Peña,Rafael Solana,John E. Coligan +7 more
TL;DR: The molecular structure, specificity, cellular expression patterns, and function of these HLA class I receptors, as well as the chromosomal location and genetic organization are discussed.
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Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1
D. C. Ghislaine Mayer,Joann Cofie,Lubin Jiang,Daniel L. Hartl,Erin Tracy,Juraj Kabat,Laurence H. Mendoza,Louis H. Miller +7 more
TL;DR: Evidence is provided that glycophorin B is a receptor for the P. falciparum protein EBL-1, a member of the Duffy-binding-like erythrocyte-binding protein (DBL-EBP) receptor family, and Interestingly, the Efe pygmies of the Ituri forest in the Democratic Republic of the Congo have the highest gene frequency of glycoph orin B-null in the world, raising the possibility that the DBL
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Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione
Dipak Kumar Raj,Jianbing Mu,Hongying Jiang,Juraj Kabat,Subash Singh,Margery Sullivan,Michael P. Fay,Thomas F. McCutchan,Xin-zhuan Su +8 more
TL;DR: The results suggest that PfMRP plays a role in the efflux of glutathione, CQ, and QN and contributes to parasite responses to multiple antimalarial drugs, possibly by pumping drugs outside the parasite.