D
D Coppola
Researcher at Thomas Jefferson University
Publications - 2
Citations - 897
D Coppola is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Growth factor receptor & Growth factor. The author has an hindex of 2, co-authored 2 publications receiving 888 citations.
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Journal ArticleDOI
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.
Christian Sell,Guillaume Duménil,C Deveaud,Masahiko Miura,D Coppola,Tiziana DeAngelis,Raphael Rubin,Argiris Efstratiadis,Renato Baserga +8 more
TL;DR: Reintroduction into R- cells (or their derivatives) of a plasmid expressing the human insulin-like growth factor I receptor RNA and protein restores their ability to grow with purified growth factors or in soft agar.
Journal ArticleDOI
A functional insulin-like growth factor i receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor
D Coppola,Andres Ferber,Masahiko Miura,Christian Sell,Consuelo D'Ambrosio,Raphael Rubin,Renato Baserga +6 more
TL;DR: The results indicate that at least in mouse embryo fibroblasts, the EGFR requires the presence of a functional IGF-I receptor for its mitogenic and transforming activities.