Raphael Rubin

TL;DR: Results demonstrate that signaling via the IGF-I receptor is an indispensable component of the SV40 transformation pathway, and is further supported from the results of antisense RNA experiments with tumor cell lines showing that interference with the function of the IGF -I receptor has a profound effect on anchorage-independent growth, even under conditions that only modestly affect growth in monolayers.

TL;DR: Reintroduction into R- cells (or their derivatives) of a plasmid expressing the human insulin-like growth factor I receptor RNA and protein restores their ability to grow with purified growth factors or in soft agar.

TL;DR: It is concluded that the IGF-IR activated by its ligands plays a very important protective role in programmed cell death, and that its protective action is even more striking in vivo than in vitro.

TL;DR: The results indicate that at least in mouse embryo fibroblasts, the EGFR requires the presence of a functional IGF-I receptor for its mitogenic and transforming activities.

TL;DR: The fact that the injection of C6 cells expressing an antisense RNA to IGF-1R RNA leads to regression of already established wild-type C6 tumors suggests the possibility of practical applications and demonstrates the critical importance of the IGF- 1R in glioblastoma cell growth, clonogenicity, and tumorigenicity.