D.G. Müller

TL;DR: The study proved that the follicular route play an important role in determining the kinetics of drug transfer from liposomes into the skin and indicates that an optimum particle size for optimal drug delivery exists.

TL;DR: It was concluded that the most reliable parameter for transdermal absorption was the lipophilic character of a drug (logP value) and the molecular mass, solubility constraint and percentage unionized moiety can only be used in combination with other properties in the prediction of possible transDermal drug delivery.

TL;DR: The physical stability of the four liposomal systems was determined on storage at 4 and 25°C over a 6-month period as discussed by the authors, based on a correlation of the mean volume diameter, zeta potential and pH lead to the conclusion that stability follows the order of egg lecithin (PC)/cholesterol (CH)/stearylamine (SA) < PC/CH/phosphatidylserine (PS) < bovine brain ceramides (CM)/CH/palmitic acid (PA)/CS < PC/(CH

TL;DR: A subjective, semi-quantitative assessment of histological changes to excised nude mouse skin was done using light microscopy, which showed that excised skin undergoes sub-lethal injury (necrosis) during in vitro experiments, which may lead to increased permeability of the drug.

TL;DR: It was concluded that the most reliable parameter was the lipophilic character of a drug (log P value) and all the parameters including the pharmacokinetic properties of drugs should be considered in combination in the prediction of possible transdermal drug delivery.