There is a special reason for reviewing this book at this time: it is the 50th edition of a compendium that is known and used frequently in most chemical and physical laboratories in many parts of the world. Surely, a publication that has been published for 56 years, withstanding the vagaries of science in this century, must have had something to offer. There is another reason: while the book is a standard fixture in most chemical and physical laboratories, including those in medical centers, it is not as frequently seen in the laboratories of physician's offices (those either in solo or group practice). I believe that the Handbook can be useful in those laboratories. One of the reasons, among others, is that the various basic items of information it offers may be helpful in new tests, either physical or chemical, which are continuously being published. The basic information may relate

Handbook of Chemistry and Physics

Toxicity of cationic lipids and cationic polymers in gene delivery.

Lipid-based drug delivery systems, or lipidic carriers, are being extensively employed to enhance the bioavailability of poorly-soluble drugs. They have the ability to incorporate both lipophilic and hydrophilic molecules and protecting them against degradation in vitro and in vivo. There is a number of physical attributes of lipid-based nanocarriers that determine their safety, stability, efficacy, as well as their in vitro and in vivo behaviour. These include average particle size/diameter and the polydispersity index (PDI), which is an indication of their quality with respect to the size distribution. The suitability of nanocarrier formulations for a particular route of drug administration depends on their average diameter, PDI and size stability, among other parameters. Controlling and validating these parameters are of key importance for the effective clinical applications of nanocarrier formulations. This review highlights the significance of size and PDI in the successful design, formulation and development of nanosystems for pharmaceutical, nutraceutical and other applications. Liposomes, nanoliposomes, vesicular phospholipid gels, solid lipid nanoparticles, transfersomes and tocosomes are presented as frequently-used lipidic drug carriers. The advantages and limitations of a range of available analytical techniques used to characterize lipidic nanocarrier formulations are also covered.

Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems.

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.

Nearly 50 years ago, Chase published a review of hair cycling in which he detailed hair growth in the mouse and integrated hair biology with the biology of his day. In this review we have used Chas...

/pdf/controls-of-hair-follicle-cycling-2h0o2ckdy0.pdf

Controls of hair follicle cycling.

Liposomes as Carriers for Topical and Transdermal Delivery

Topical transport of hydrophilic compounds using water-in-oil nanoemulsions

The influence of particle size of liposomes on the deposition of drug into skin

https://deepblue.lib.umich.edu/bitstream/handle/2027.42/28412/0000187.pdf?sequence=1

Norman D. Weiner

Papers

Liposomes as Carriers for Topical and Transdermal Delivery

Topical transport of hydrophilic compounds using water-in-oil nanoemulsions

The influence of particle size of liposomes on the deposition of drug into skin

Liposomes as a topical drug delivery system

Application of membrane-based dendrimer/DNA complexes for solid phase transfection in vitro and in vivo.