The influence of particle size of liposomes on the deposition of drug into skin
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TLDR
The study proved that the follicular route play an important role in determining the kinetics of drug transfer from liposomes into the skin and indicates that an optimum particle size for optimal drug delivery exists.About:
This article is published in International Journal of Pharmaceutics.The article was published on 1994-03-30 and is currently open access. It has received 188 citations till now. The article focuses on the topics: Drug delivery & Drug carrier.read more
Citations
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Journal ArticleDOI
Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems.
M. Danaei,M Dehghankhold,Sara Ataei,F Hasanzadeh Davarani,R. Javanmard,A Dokhani,Saied Nouri Khorasani,Mohammad Reza Mozafari +7 more
TL;DR: This review highlights the significance of size and PDI in the successful design, formulation and development of nanosystems for pharmaceutical, nutraceutical and other applications.
Journal ArticleDOI
Grey Goo on the Skin? Nanotechnology, Cosmetic and Sunscreen Safety
TL;DR: Overall, the current weight of evidence suggests that nano-materials such as nano-sized vesicles or TiO2 and ZnO nanoparticles currently used in cosmetic preparations or sunscreens pose no risk to human skin or human health, although other NP may have properties that warrant safety evaluation on a case-by-case basis before human use.
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Structure of the skin barrier and its modulation by vesicular formulations.
TL;DR: In order to unravel the mechanisms involved in increasing the drug transport across the skin, information on the effect of vesicles on drug permeation rate, the permeation pathway and perturbations of the skin ultrastructure is of importance.
Journal ArticleDOI
Skin penetration and distribution of polymeric nanoparticles
TL;DR: Confocal laser scanning microscopy was used to visualize the distribution of non-biodegradable, fluorescent, polystyrene nanoparticles across porcine skin and revealed that these non-follicular structures did not offer an alternative penetration pathway for the polymer vectors, whose transport was clearly impeded by the stratum corneum.
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Particle size of liposomes influences dermal delivery of substances into skin.
TL;DR: The results indicated that the CF penetration was inversely related to the size of the liposomes, which was confirmed by the data of the confocal laser scanning microscopy studies.
References
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Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation
TL;DR: A substantial fraction of the aqueous phase is entrapped within the vesicles, encapsulating even large macromolecular assemblies with high efficiency, and has unique advantages for encapsulating valuable water-soluble materials such as drugs, proteins, nucleic acids, and other biochemical reagents.
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Epidermal lipids, barrier function, and desquamation.
TL;DR: A heterogeneous two-compartment model of the stratum corneum that ascribes a special role for intercellular lipids in the regulation of stratum Corneum barrier function and desquamation is proposed.
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Liposomes - a selective drug delivery system for the topical route of administration I. Lotion dosage form
TL;DR: The liposomal encapsulation favourably altered the drug dipposition; the concentration of the drug decreased at the site of its adverse effects and increased at the sites where its activity is desired.
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Studies on contact sensitivity to chromium in the guinea pig. The role of valence in the formation of the antigenic determinant.
TL;DR: From the failure to select lymphocytes directed specifically against a chromium determinant of a particular valence it is concluded that by sensitization with chromium salts of different valences a common determinant or closely related determinants are formed.
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Percutaneous Transport in Relation to Stratum Corneum Structure and Lipid Composition
Peter M. Elias,Peter M. Elias,Eugene R. Cooper,Eugene R. Cooper,Antoinette Korc,Antoinette Korc,Barbara E. Brown,Barbara E. Brown +7 more
TL;DR: Differences in the thickness and the number of cell layers in the stratum corneum are insufficient to account for differences in percutaneous transport across leg and abdomen, and total lipid concentration may be the critical factor governing skin permeability.
Related Papers (5)
Particle size of liposomes influences dermal delivery of substances into skin.
Liposomes - a selective drug delivery system for the topical route of administration I. Lotion dosage form
Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force.
Gregor Cevc,Gabriele Blume +1 more