D
D. Gothard
Researcher at University of Southampton
Publications - 12
Citations - 476
D. Gothard is an academic researcher from University of Southampton. The author has contributed to research in topics: Bone regeneration & Tissue engineering. The author has an hindex of 10, co-authored 12 publications receiving 423 citations. Previous affiliations of D. Gothard include University of Nottingham.
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Journal ArticleDOI
Tissue engineered bone using select growth factors: A comprehensive review of animal studies and clinical translation studies in man.
D. Gothard,Emma L. Smith,Janos M. Kanczler,Hassan Rashidi,Omar Qutachi,James R. Henstock,Michael Rotherham,A.J. El Haj,Kevin M. Shakesheff,Richard O.C. Oreffo +9 more
TL;DR: Focus is drawn to the in vivo success of osteoinductive growth factors incorporated within material implants both in animals and humans, and identifies the unmet challenges within the skeletal regenerative area.
Journal ArticleDOI
In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors
D. Gothard,Emma L. Smith,Janos M. Kanczler,Cameron Black,Julia Wells,C. Roberts,Lisa J. White,Omar Qutachi,Heather Peto,Hassan Rashidi,Luis Rojo,Molly M. Stevens,Molly M. Stevens,Alicia J. El Haj,Felicity R. A. J. Rose,Kevin M. Shakesheff,Richard O.C. Oreffo +16 more
TL;DR: ALG/ECM hydrogels provide a versatile biomaterial scaffold for utilisation within regenerative medicine which may be tailored, ultimately, to form the tissue of choice through incorporation of select growth factors.
Journal ArticleDOI
Evaluation of skeletal tissue repair, part 1: assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model.
Emma L. Smith,Janos M. Kanczler,D. Gothard,C. Roberts,Julia Wells,Lisa J. White,Omar Qutachi,Michael J. Sawkins,Heather Peto,Hassan Rashidi,Luis Rojo,Molly M. Stevens,A.J. El Haj,Felicity R. A. J. Rose,Kevin M. Shakesheff,Richard O.C. Oreffo +15 more
TL;DR: Delivery of bioactive growth factors from a novel alginate/bECM hydrogel to augment skeletal tissue formation and the use of an organotypic chick femur defect culture system as a high-throughput test model for scaffold/cell/growth factor therapies for regenerative medicine are demonstrated.
Journal ArticleDOI
Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model
Emma L. Smith,Janos M. Kanczler,D. Gothard,C. Roberts,Julia Wells,Lisa J. White,Omar Qutachi,Michael J. Sawkins,Heather Peto,Hassan Rashidi,Luis Rojo,Molly M. Stevens,A.J. El Haj,Felicity R. A. J. Rose,Kevin M. Shakesheff,Richard O.C. Oreffo +15 more
TL;DR: An ex vivo embryonic chick femur critical size defect model is developed and applied in the study of novel extracellular matrix (ECM) hydrogel scaffolds containing spatio-temporal combinatorial growth factor-releasing microparticles and skeletal stem cells for bone regeneration.
Journal ArticleDOI
Controlled embryoid body formation via surface modification and avidin–biotin cross-linking
TL;DR: It is demonstrated that engineering accelerates ES cell aggregation, forming larger, denser and more stable EBs than control samples, with no significant decrease in constituent ES cell viability, but extended culture reveals significant core necrosis creating a layered EB structure.