D
D R Maneval
Researcher at University of Maryland, Baltimore
Publications - 11
Citations - 1172
D R Maneval is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Shigella flexneri & Enterotoxigenic Escherichia coli. The author has an hindex of 11, co-authored 11 publications receiving 1143 citations.
Papers
More filters
Journal ArticleDOI
Aggregative adherence fimbriae I of enteroaggregative Escherichia coli mediate adherence to HEp-2 cells and hemagglutination of human erythrocytes.
TL;DR: Cl cloning of the AA determinant from EAggEC strain 17-2 into the 21.5-kb cosmid vector pCVD301 is reported and is termed the cloned bundle-forming fimbriae aggregative adherence fimbRIae I (AAF/I); positivity with a previously describedEAggEC probe and human erythrocyte HA appear to correlate with the presence of AAF/I.
Journal ArticleDOI
Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains.
James P. Nataro,J Seriwatana,Alessio Fasano,D R Maneval,Linda Guers,Fernando R. Noriega,F Dubovsky,Myron M. Levine,J G Morris +8 more
TL;DR: A deletion in the EIEC sen gene was constructed by allelic exchange, resulting in significantly lower rises in Isc than were elicited by the wild-type parent; however, significant enterotoxic activity remained in the sen deletion mutant.
Journal ArticleDOI
Shigella enterotoxin 1: an enterotoxin of Shigella flexneri 2a active in rabbit small intestine in vivo and in vitro.
Alessio Fasano,Fernando R. Noriega,D R Maneval,Somchoke Chanasongcram,R. Russell,Stefano Guandalini,Myron M. Levine +6 more
TL;DR: Observations suggest that S. flexneri 2a elaborates two distinct enterotoxins: ShET1, encoded by genes located on the chromosome, and ShET2, encoding by a gene on the 140-MD invasiveness plasmid, may be important in the pathogenesis of diarrheal illness due to S.flexneri 1a.
Journal ArticleDOI
Strategy for Cross-Protection among Shigella flexneri Serotypes
TL;DR: The combination vaccine conferred significant protection against challenge with S. flexneri serotype 1a, 1b, 2b, 4b, 5b, Y, or 6 strain of demonstrated virulence in the same model.
Journal ArticleDOI
Purification, morphology, and genetics of a new fimbrial putative colonization factor of enterotoxigenic Escherichia coli O159:H4.
TL;DR: A distinct plasmid-encoded fimbria composed of 19-kilodalton protein subunits associated with ETEC serotype O159:H4 is found, which joins other ETEC fimbriae as potentially useful immunogens against human diarrhea.