D. Riche

TL;DR: Serial events offer a new method to induce spontaneous recurrent seizures with brain damage in Wistar rats and Neuropathological examination revealed dose-dependent alterations.

TL;DR: A hypothesis is presented for the observed abnormal movements suggesting that the CP lesions reduce movement thresholds while the activation of dopaminoceptive regions induces dyskinesias.

TL;DR: It is confirmed that chronic mitochondrial complex I inhibition using MPTP in primates is sufficient to reproduce the typical dopaminergic cell loss and striatal fibre depletion observed in Parkinson's disease.

TL;DR: Observations and behavioural data show that chronic rather than acute MPTP injection regimens can replicate most of the neuropathological and the clinical features typical of idiopathic Parkinson's disease, possibly by increasing the ability of this neurotoxin to target specific subpopulations of mesencephalic dopaminergic neurons.

TL;DR: The implantation of cross-species striatal neural precursor cells into the lesioned striatum of nonhuman primates (baboons) reduced the abnormal movements seen in the disease model and encouraged the use of cell sources other than human fetal cells in a potential clinical application to Huntington disease.