D
D. van Velzen
Researcher at University of Antwerp
Publications - 4
Citations - 486
D. van Velzen is an academic researcher from University of Antwerp. The author has contributed to research in topics: Hearing loss & Sensorineural hearing loss. The author has an hindex of 4, co-authored 4 publications receiving 465 citations.
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Journal ArticleDOI
The full mutation in the FMR–1 gene of male fragile X patients is absent in their sperm
Edwin Reyniers,L Vits,K. De Boulle,B. Van Roy,D. van Velzen,E. de Graaff,Anton Verkerk,H Z Jorens,John K. Darby,Ben A. Oostra +9 more
TL;DR: Study of FMR–1 in sperm of four male fragile X patients showed that only the premutation was present in their sperm, although they had a full mutation in peripheral lymphocytes, which might suggest that expansion of the premutations to the full mutations in FMR-1 does not occur in meiosis but in a postzygotic stage.
Journal ArticleDOI
Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families.
Paul Coucke,P. van Hauwe,P.M. Kelley,Henricus P. M. Kunst,Isabelle Schatteman,D. van Velzen,J. Meyers,R.J.H. Ensink,M. Verstreken,Frank Declau,Henri A. M. Marres,K. Kastury,Shalender Bhasin,Wyman T. McGuirt,Richard J.H. Smith,C.W.R.J. Cremers,P. Van de Heyning,P.H.G.M. Willems,Shelley D. Smith,G. Van Camp +19 more
TL;DR: The results indicate that at least two and possibly three genes responsible for hearing impairment are located close together on chromosome 1p34 and suggest that KCNQ4 mutations may be a relatively frequent cause of autosomal dominant hearing loss.
Journal ArticleDOI
Linkage analysis of progressive hearing loss in five extended families maps the DFNA2 gene to a 1.25-Mb region on chromosome 1p.
G. Van Camp,Paul Coucke,Henricus P. M. Kunst,Isabelle Schatteman,D. van Velzen,Henri A. M. Marres,M. van Ewijk,Frank Declau,P. van Hauwe,J. Meyers,J. B. Kenyon,Shelley D. Smith,Richard J.H. Smith,Bulantrisna Djelantik,Cor W. R. J. Cremers,P. Van de Heyning,P.H.G.M. Willems +16 more
TL;DR: Linkage to DFNA2 is reported in three additional large families with autosomal dominant hearing loss from Belgium and The Netherlands, indicating that DFNA 2 is most likely an important gene for autosomal dominance hearing loss.
Journal Article
Audiometric analysis of a Belgian family linked to the DFNA10 locus.
M. Verstreken,Frank Declau,Isabelle Schatteman,D. van Velzen,Kristien Verhoeven,G. Van Camp,P. J. Willems,E. W. Kuhweide,E. Verhaert,Patrick S. C. D’Haese,Floris L. Wuyts,P. Van de Heyning +11 more
TL;DR: The genetically affected persons of a Belgian family shared a progressive symmetric sensorineural hearing loss that started in the first to fourth decade that was initially mild, with a spontaneous evolution to a moderate or severe hearing impairment.