Daan J.A. Crommelin

TL;DR: It is shown that physical degradation of the proteins as well as chemical decomposition may enhance the immune response, and to what extent the presence of degradation products in protein formulations influences their immunogenicity still needs further investigation.

TL;DR: The use of model peptides enabled us to determine the reactivity of each particular cross-link reaction as a function of the reaction conditions and to identify new reaction products after incubation with formaldehyde.

TL;DR: The purpose of this commentary is to provide brief summaries on the factors affecting protein aggregation and the key aspects of protein aggregation that are associated with immunogenicity, and emphasize the current scientific gaps in understanding and analytical limitations for quantitation of species of large protein aggregates that are referred to as subvisible particles.

TL;DR: In this article, the authors discuss the structure of mRNA-LNPs, factors that impact their stability, and strategies to optimize them to improve the product stability of COVID-19 vaccines.

TL;DR: In the first part of this article, chemical and physical stability of aqueous liposome dispersions have been addressed and a HPLC method with a refractive index detector for the analysis of phospholipids from aqueously liposomes dispersions is described.