D
Dafna Geblinger
Researcher at Weizmann Institute of Science
Publications - 5
Citations - 514
Dafna Geblinger is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Podosome & Bone cell. The author has an hindex of 5, co-authored 5 publications receiving 481 citations.
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Journal ArticleDOI
The Architecture of the Adhesive Apparatus of Cultured Osteoclasts: From Podosome Formation to Sealing Zone Assembly
Chen Luxenburg,Dafna Geblinger,Eugenia Klein,Karen L. Anderson,Dorit Hanein,Benny Geiger,Lia Addadi +6 more
TL;DR: The molecular architecture of the osteoclast resorptive apparatus is mapped from individual podosomes to the sealing zone, at an unprecedented resolution, forming a unique continuous functional structure connecting the cell to its extracellular milieu.
Journal ArticleDOI
Nano-topography sensing by osteoclasts.
TL;DR: It was observed that steps or sub-micrometer cracks on the smooth surface stimulate local ring formation, raising the possibility that similar imperfections on bone surfaces may stimulate local osteoclast resorptive activity.
Journal ArticleDOI
Substrate adhesion regulates sealing zone architecture and dynamics in cultured osteoclasts.
Fabian Anderegg,Dafna Geblinger,Peter Horvath,Mirren Charnley,Marcus Textor,Lia Addadi,Benjamin Geiger +6 more
TL;DR: By growing differentiated osteoclasts on micro-patterned glass substrates, it is shown that SZ growth and fusion strictly depend on the continuity of substrate adhesiveness, at the micrometer scale.
Journal ArticleDOI
Surface-Induced Regulation of Podosome Organization and Dynamics in Cultured Osteoclasts
TL;DR: It is concluded that osteoclasts sense the local properties of the underlying substrate and respond to these signals, both locally and globally.
Journal ArticleDOI
Effects of surface microtopography on the assembly of the osteoclast resorption apparatus
TL;DR: It is proposed that sealing-zone dynamics, while being locally regulated by surface roughness, are globally integrated via the associated actin cytoskeleton.