P
Peter Horvath
Researcher at Semmelweis University
Publications - 335
Citations - 10616
Peter Horvath is an academic researcher from Semmelweis University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 41, co-authored 299 publications receiving 7349 citations. Previous affiliations of Peter Horvath include University of Pécs & ETH Zurich.
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Journal ArticleDOI
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
Carly G. K. Ziegler,Samuel J. Allon,Sarah K. Nyquist,Ian M. Mbano,Vincent N. Miao,Constantine N. Tzouanas,Yuming Cao,Ashraf S. Yousif,Julia Bals,Blake M. Hauser,Blake M. Hauser,Jared Feldman,Jared Feldman,Christoph Muus,Christoph Muus,Marc H. Wadsworth,Samuel W. Kazer,Travis K. Hughes,Benjamin Doran,G. James Gatter,G. James Gatter,G. James Gatter,Marko Vukovic,Faith Taliaferro,Faith Taliaferro,Benjamin E. Mead,Zhiru Guo,Jennifer P. Wang,Delphine Gras,Magali Plaisant,Meshal Ansari,Ilias Angelidis,Heiko Adler,Jennifer M.S. Sucre,Chase J. Taylor,Brian M. Lin,Avinash Waghray,Vanessa Mitsialis,Vanessa Mitsialis,Daniel F. Dwyer,Kathleen M. Buchheit,Joshua A. Boyce,Nora A. Barrett,Tanya M. Laidlaw,Shaina L. Carroll,Lucrezia Colonna,Victor Tkachev,Victor Tkachev,Christopher W. Peterson,Christopher W. Peterson,Alison Yu,Alison Yu,Hengqi Betty Zheng,Hengqi Betty Zheng,Hannah P. Gideon,Caylin G. Winchell,Philana Ling Lin,Philana Ling Lin,Colin D. Bingle,Scott B. Snapper,Scott B. Snapper,Jonathan A. Kropski,Jonathan A. Kropski,Fabian J. Theis,Herbert B. Schiller,Laure-Emmanuelle Zaragosi,Pascal Barbry,Alasdair Leslie,Alasdair Leslie,Hans-Peter Kiem,Hans-Peter Kiem,JoAnne L. Flynn,Sarah M. Fortune,Sarah M. Fortune,Sarah M. Fortune,Bonnie Berger,Robert W. Finberg,Leslie S. Kean,Leslie S. Kean,Manuel Garber,Aaron G. Schmidt,Aaron G. Schmidt,Daniel Lingwood,Alex K. Shalek,Jose Ordovas-Montanes,Nicholas E. Banovich,Alvis Brazma,Tushar J. Desai,Thu Elizabeth Duong,Oliver Eickelberg,Christine S. Falk,Michael Farzan,Ian A. Glass,Muzlifah Haniffa,Peter Horvath,Deborah T. Hung,Naftali Kaminski,Mark A. Krasnow,Malte Kühnemund,Robert Lafyatis,Haeock Lee,Sylvie Leroy,Sten Linnarson,Joakim Lundeberg,Kerstin B. Meyer,Alexander V. Misharin,Martijn C. Nawijn,Marko Nikolic,Dana Pe'er,Joseph E. Powell,Stephen R. Quake,Jay Rajagopal,Purushothama Rao Tata,Emma L. Rawlins,Aviv Regev,Paul A. Reyfman,Mauricio Rojas,Orit Rosen,Kourosh Saeb-Parsy,Christos Samakovlis,Herbert B. Schiller,Joachim L. Schultze,Max A. Seibold,Douglas P. Shepherd,Jason R. Spence,Avrum Spira,Xin Sun,Sarah A. Teichmann,Fabian J. Theis,Alexander M. Tsankov,Maarten van den Berge,Michael von Papen,Jeffrey A. Whitsett,Ramnik J. Xavier,Yan Xu,Kun Zhang +135 more
TL;DR: The data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.
Journal ArticleDOI
Neuropilin-1 is a host factor for SARS-CoV-2 infection.
James L. Daly,Boris Simonetti,Katja Klein,Kai-En Chen,Maia Kavanagh Williamson,Carlos Antón-Plágaro,Deborah K. Shoemark,Lorena Simón-Gracia,Michael Bauer,Reka Hollandi,Urs F. Greber,Peter Horvath,Peter Horvath,Richard B. Sessions,Ari Helenius,Julian A. Hiscox,Julian A. Hiscox,Tambet Teesalu,David A. Matthews,Andrew D. Davidson,Brett M. Collins,Peter J. Cullen,Yohei Yamauchi,Yohei Yamauchi +23 more
TL;DR: It is shown that neuropilin-1 (NRP1), which is known to bind furin-cleaved substrates, potentiates SARS-CoV-2 infectivity and serves as a host factor for Sars-Cov-2 infection and may potentially provide a therapeutic target for COVID-19.
Journal ArticleDOI
Data-analysis strategies for image-based cell profiling
Juan C. Caicedo,Sam Cooper,Florian Heigwer,Scott Warchal,Peng Qiu,Csaba Molnar,Aliaksei Vasilevich,Joseph Barry,Harmanjit Singh Bansal,Oren Kraus,Mathias Wawer,Lassi Paavolainen,Markus D. Herrmann,Mohammad Hossein Rohban,Jane Hung,Jane Hung,Holger Hennig,John Concannon,Ian Smith,Paul A. Clemons,Shantanu Singh,Paul Rees,Paul Rees,Peter Horvath,Peter Horvath,Roger G. Linington,Anne E. Carpenter +26 more
TL;DR: The steps required to create high-quality image-based (i.e., morphological) profiles from a collection of microscopy images are introduced and techniques that have proven useful in each stage of the data analysis process are recommended on the basis of the experience of 20 laboratories worldwide that are refining their image- based cell-profiling methodologies.
Posted ContentDOI
Neuropilin-1 is a host factor for SARS-CoV-2 infection
James L. Daly,Boris Simonetti,Carlos Antón-Plágaro,Maia Kavanagh Williamson,Deborah K. Shoemark,Lorena Simón-Gracia,Katja Klein,Michael Bauer,Reka Hollandi,Urs F. Greber,Peter Horvath,Richard B. Sessions,Ari Helenius,Julian A. Hiscox,Tambet Teesalu,David A. Matthews,Andrew D. Davidson,Peter J. Cullen,Yohei Yamauchi +18 more
TL;DR: Here it is demonstrated using immunoprecipitation, site-specific mutagenesis, structural modelling, and antibody blockade that S1 can bind to NRP1 through the canonical CendR mechanism, and this interaction enhances infection by SARS-CoV-2 in cell culture.
Journal ArticleDOI
Screening out irrelevant cell-based models of disease
Peter Horvath,Peter Horvath,Nathalie Aulner,Marc Bickle,Anthony Davies,Anthony Davies,Elaine Del Nery,Daniel Ebner,María C. Montoya,Päivi Östling,Päivi Östling,Vilja Pietiäinen,Leo S. Price,Spencer L. Shorte,Gerardo Turcatti,Carina von Schantz,Neil O. Carragher +16 more
TL;DR: In this article, the authors propose a set of principles to facilitate the definition and development of disease-relevant assays, and discuss new opportunities for exploiting the latest advances in cell-based assay technologies in drug discovery.