Dagmar Pretsch

TL;DR: Compound C has effective antimicrobial activity against P. acnes and anti-inflammatory activity, and it is suggested that this substance or the crude extract from T. wortmannii are alternative treatments for antibiotic/anti-inflammatory therapy for acne vulgaris.

TL;DR: 4-DACL treatment induced mitochondrial ROS, reduced NF-κB signaling activity and increased up-regulation of the cell cycle inhibitors cyclin-dependent kinase inhibitor p21 and the tumor suppressor protein p53 in a dose-dependent manner, which was accompanied by decreased cell proliferation and apoptosis via the intrinsic pathway.

TL;DR: A phenotype-directed in vivo approach opens up new horizons for the selection of natural starting materials and the investigation of their active principles as fast drug discovery tool with predictive value for human diseases.

TL;DR: This work demonstrates that biologically active 3D libraries are readily available by manipulation of a tetramate skeleton, and shows high antibacterial activity coupled with modest gyrase/polymerase activity in two cases.

TL;DR: Metallothionein (MT), an endogenous metal detoxifying protein, is increased in young amyloid ß (Aß) expressing Caenorhabditis elegans, whereas it is not in wild type strains, indicating the age dependency of disease outbreak, and sharing intriguing parallels to diminished MT levels in human brains of AD.