Dagmar Stropova

TL;DR: In situ perfusion showed that brain uptake was improved by up to 98% for several of the glycosylated peptides, and the nociceptive profiles of the peptides followed the rank order of peptide entry to the brain with up to a 39-fold increase in A.C.U.

TL;DR: DPDPE, a series of small organic peptide mimetic compounds targeted for the δ-opioid receptor, uses piperazine as a template to present the most important pharmacophore groups, including phenol and phenyl groups and a hydrophobic moiety to increase the binding affinity and selectivity of these non-peptide ligands.

TL;DR: PWR spectroscopy demonstrated that cannabinoid agonists exhibit high affinity for the purified epitope tagged hCB(1) receptor, while PWR experiments indicated that these CP 55,940-and WIN 55,212-bound hCB1 receptor conformations exhibit slightly different affinities to an inhibitory G protein heterotrimer, Gi1.

TL;DR: Treatment of Chinese hamster ovary cells with the selective Raf-1 inhibitor GW5074 attenuates chronic deltorphin II-mediated increase in forskolin-stimulated cAMP formation by 40% and should aid in the development of analgesics that act longer and have fewer side effects.

TL;DR: It is hypothesized that parallel calmidazolium, chelerythrine, and genistein-sensitive pathways converge at Raf-1 to mediate AC superactivation by phosphorylating AC VI in hDOR/CHO cells.