D
Dagmar Wilhelm
Researcher at University of Melbourne
Publications - 103
Citations - 9264
Dagmar Wilhelm is an academic researcher from University of Melbourne. The author has contributed to research in topics: Testis determining factor & Regulation of gene expression. The author has an hindex of 47, co-authored 99 publications receiving 8462 citations. Previous affiliations of Dagmar Wilhelm include University of Adelaide & Boston Children's Hospital.
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Journal ArticleDOI
Retinoid Signaling Determines Germ Cell Fate in Mice
Josephine Bowles,D. Knight,Christopher A. Smith,Dagmar Wilhelm,Joy M. Richman,Joy M. Richman,Satoru Mamiya,Kenta Yashiro,Kallayanee Chawengsaksophak,Megan J. Wilson,Janet Rossant,Hiroshi Hamada,Peter Koopman +12 more
TL;DR: It is found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and inititate oogenesis, and precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate.
Journal ArticleDOI
ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.
TL;DR: The data demonstrate that distinct signal transduction pathways converge at c‐Jun/ATF‐2, whereby each subunit is individually addressed by a specific class of protein kinases, which allows fine tuned modulation of c‐jun expression by a large spectrum of extracellular signals.
Journal ArticleDOI
Sex Determination and Gonadal Development in Mammals
TL;DR: The growing body of knowledge relating to testis development and the beginnings of a picture of ovary development together illustrate the complex mechanisms by which these organ systems develop, inform the etiology, diagnosis, and management of disorders of sexual development, and help define what it is to be male or female.
Journal ArticleDOI
Sox18 induces development of the lymphatic vasculature in mice
Mathias Francois,Andrea Caprini,Brett M. Hosking,Fabrizio Orsenigo,Dagmar Wilhelm,Catherine M. Browne,Karri Paavonen,Tara Karnezis,Ramin Shayan,Ramin Shayan,Meredith Downes,Tara-Lynne Davidson,D. Tutt,Kathryn S.E. Cheah,Steven A. Stacker,George E.O. Muscat,Marc G. Achen,Elisabetta Dejana,Peter Koopman +18 more
TL;DR: A critical role is demonstrated for Sox18 in developmental lymphangiogenesis, and new avenues to investigate for therapeutic management of human lymphangiopathies are suggested.
Journal Article
Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro.
TL;DR: It is shown that CBP also stimulates the activity of both c-Jun and v-Jun in vivo, consistent with a mechanism by which CBP acts as a co-activator protein for Jun dependent transcription by interacting with the Jun N-terminal activation domain.