Dale L. Goad

TL;DR: It is suggested that Indian hedgehog positively controls differentiation of periarticular chondrocytes independently of PTHrP, which indicates that chONDrocyte differentiation is controlled at multiple steps by P THrP and Ihh through the mutual regulation of their activities.

TL;DR: Testing the hypothesis that insulin-like growth factor I (IGF-I), a known osteogenic factor, modulates VEGF expression in osteoblasts concludes that IGF-I enhances osteoblast synthesis of V EGF, which may then act locally on endothelium to stimulate angiogenesis, an essential component of bone growth and remodeling.

TL;DR: The findings indicate that a host factor produced in response to malignant cells can cause enhanced bone resorption, and the concept of the humoral hypercalcemias of malignancy must be expanded to include mediators not produced by the tumor cells themselves.

TL;DR: HPTHrP-(1-34) and hPTH-related protein have similar high specific biological activities to stimulate production of cAMP in human osteoblast-like cells, but that hP THrP-1- 34 is modestly less potent to stimulate bone resorption in mouse calvariae.

TL;DR: It is found that physiologically relevant concentrations of IGF-I specifically inhibited PTH-stimulated and enhanced PGE2- Stimulated production of cAMP by an action at the level of PTH and P GE2 receptors and/or coupling of the receptors to Gs alpha.