Damian K. Dowling

TL;DR: This review reviews the evidence in support of the contention that ROS production will constitute a primary and universal constraint in life-history evolution, and integrates the above suggestions into one life- history framework.

TL;DR: The latest findings that show mitochondrial and cytoplasmic genetic variation for life-history traits and fitness and the key importance of the mitochondrial-nuclear interaction as a unit of selection are reviewed.

TL;DR: This work expresses five mitochondrial variants alongside a standard nuclear genome in Drosophila melanogaster and finds striking sexual asymmetry in patterns of nuclear gene expression, suggesting an evolutionary mechanism that results in mitochondrial genomes harboring male-specific mutation loads.

TL;DR: The findings suggest that males are subject to dramatic consequences that result from the maternal transmission of mitochondrial genomes, and implicate the diminutive mitochondrial genome as a hotspot for mutations that affect sex-specific patterns of aging, promoting the idea that a sex- specific selective sieve in mitochondrial genome evolution is a contributing factor to sexual dimorphism in aging.

TL;DR: Evidence is compiled that suggests that mitochondrial–nuclear (mitonuclear) allelic interactions are evolutionarily significant modulators of the expression of key health-related and life-history phenotypes, across several biological scales—within species (intra- and interpopulational) and between species.