D
Dan Feng
Researcher at University of Pennsylvania
Publications - 26
Citations - 4156
Dan Feng is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Circadian rhythm. The author has an hindex of 17, co-authored 17 publications receiving 3615 citations. Previous affiliations of Dan Feng include Lucile Packard Children's Hospital & Tsinghua University.
Papers
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Journal ArticleDOI
PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale
Martina I. Lefterova,Yong Zhang,David J. Steger,Michael Schupp,Jonathan Schug,Ana G. Cristancho,Dan Feng,David Zhuo,Christian J. Stoeckert,X. Shirley Liu,Mitchell A. Lazar +10 more
TL;DR: Peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor and the target of anti-diabetic thiazolinedione drugs, and C/EBPbeta also plays a role at many of these genes, such that both C/EBPalpha and beta are required along with PPARGamma for robust adipocyte-specific gene expression.
Journal ArticleDOI
A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism
Dan Feng,Tao Liu,Zheng Sun,Anne Bugge,Shannon E. Mullican,Theresa Alenghat,X. Shirley Liu,Mitchell A. Lazar +7 more
TL;DR: It is shown that genomic recruitment of HDAC3 by Rev-erbα directs a circadian rhythm of histone acetylation and gene expression required for normal hepatic lipid homeostasis.
Journal ArticleDOI
Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function
Anne Bugge,Dan Feng,Logan J. Everett,Erika R. Briggs,Shannon E. Mullican,Fenfen Wang,Jennifer Jager,Mitchell A. Lazar +7 more
TL;DR: These findings establish the two Rev-erbs as major regulators of both clock function and metabolism, displaying a level of subtype collaboration that is unusual among nuclear receptors but common among core clock proteins, protecting the organism from major perturbations in circadian and metabolic physiology.
Journal ArticleDOI
Nutrient-sensing nuclear receptors coordinate autophagy
TL;DR: It is shown that both PPARα and FXR regulate hepatic autophagy in mice, revealing complementary, interlocking mechanisms for regulation ofAutophagy by nutrient status.
Journal ArticleDOI
Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock
Yuxiang Zhang,Bin Fang,Matthew J. Emmett,Manashree Damle,Zheng Sun,Zheng Sun,Dan Feng,Sean M. Armour,Jarrett R. Remsberg,Jennifer Jager,Raymond E. Soccio,David J. Steger,Mitchell A. Lazar +12 more
TL;DR: It is shown that Rev-erbα modulates the clock and metabolism by different genomic mechanisms, which provides a universal mechanism for self-sustained control of the molecular clock across all tissues.