D
Dan V. Nicolau
Researcher at University of Oxford
Publications - 295
Citations - 5319
Dan V. Nicolau is an academic researcher from University of Oxford. The author has contributed to research in topics: Molecular motor & Adsorption. The author has an hindex of 37, co-authored 288 publications receiving 4538 citations. Previous affiliations of Dan V. Nicolau include University of Melbourne & Industrial Research Institute.
Papers
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Journal ArticleDOI
Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial.
Sanjay Ramakrishnan,Sanjay Ramakrishnan,Sanjay Ramakrishnan,Dan V. Nicolau,Dan V. Nicolau,Dan V. Nicolau,Beverly Langford,Beverly Langford,Mahdi Mahdi,Mahdi Mahdi,Helen Jeffers,Helen Jeffers,Christine Mwasuku,Christine Mwasuku,Karolina Krassowska,Karolina Krassowska,Robin Fox,Ian Binnian,Victoria Glover,Stephen Bright,Christopher C Butler,Jennifer L Cane,Jennifer L Cane,Andreas Halner,Philippa C Matthews,Philippa C Matthews,Louise E. Donnelly,Jodie L. Simpson,Jonathan R. Baker,Nabil T. Fadai,Stefan Peterson,Thomas Bengtsson,Peter J. Barnes,Richard Russell,Richard Russell,Mona Bafadhel,Mona Bafadhel +36 more
TL;DR: In this paper, an open-label, parallel-group, phase 2, randomised controlled trial (Steroids in COVID-19; STOIC) of inhaled budesonide, compared with usual care, in adults within 7 days of the onset of mild COPD symptoms was performed in the community in Oxfordshire, UK.
Journal ArticleDOI
Conformational Spread as a Mechanism for Cooperativity in the Bacterial Flagellar Switch
Fan Bai,Richard W. Branch,Dan V. Nicolau,Dan V. Nicolau,Teuta Pilizota,Bradley C. Steel,Philip K. Maini,Richard M. Berry +7 more
TL;DR: High-resolution optical microscopy is used to observe switching of single motors and uncover the stochastic multistate nature of the switch of the bacterial flagellar switch complex, in detailed quantitative agreement with a recent general model of allosteric cooperativity that exhibits conformational spread.
Journal ArticleDOI
Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membrane.
TL;DR: It is concluded that micro domains can readily operate as protein concentrators or isolators but there appear to be significant constraints on size and mobility if microdomains are also required to function as reaction chambers that facilitate nanoscale protein-protein interactions.
Journal Article
Conformational Spread as a Mechanism for Cooperativity in the Bacterial Flagellar Switch
Fan Bai,Richard W. Branch,Dan V. Nicolau,Dan V. Nicolau,Teuta Pilizota,Bradley C. Steel,Philip K. Maini,Richard M. Berry +7 more
TL;DR: In this paper, the authors used high-resolution optical microscopy to observe switching of single motors and uncover the stochastic multistate nature of the switch, which is in detailed quantitative agreement with a recent general model of allosteric cooperativity that exhibits conformational spread.
Journal ArticleDOI
Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial.
Ly-Mee Yu,Mona Bafadhel,Jienchi Dorward,Jienchi Dorward,Gail Hayward,Benjamin R. Saville,Oghenekome Gbinigie,Oliver van Hecke,Emma Ogburn,Philip Evans,Philip Evans,Nicholas P B Thomas,Nicholas P B Thomas,Mahendra G Patel,Duncan Richards,Nicholas Berry,Michelle A. Detry,Christina Saunders,Mark Fitzgerald,Victoria Harris,Milensu Shanyinde,Simon de Lusignan,Monique Andersson,Peter J. Barnes,Richard Russell,Dan V. Nicolau,Dan V. Nicolau,Sanjay Ramakrishnan,FD Richard Hobbs,Christopher C Butler,Nicholas Pb Thomas,Christina T Saunders,Richard Ek Russell +32 more
TL;DR: A previous efficacy trial found benefit from inhaled budesonide for COVID-19 in patients not admitted to hospital, but effectiveness in high-risk individuals is unknown as mentioned in this paper.