Dana C. Dolinoy

TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.

TL;DR: It is reported that maternal dietary genistein supplementation of mice during gestation, at levels comparable with humans consuming high-soy diets, shifted the coat color of heterozygous viable yellow agouti (Avy/a) offspring toward pseudoagouti, providing the first evidence that in utero dietarygenistein affects gene expression and alters susceptibility to obesity in adulthood by permanently altering the epigenome.

TL;DR: This review serves to integrate studies of the animal in vivo with human epidemiological data pertaining to nutritional regulation of DNA methylation and to further identify areas in which current knowledge is limited.

TL;DR: The results indicate that stochastic establishment of epigenotype at metastable epialleles is, in general, labile to methyl donor nutrition, and such influences are not limited to early embryonic development.

TL;DR: The reader is introduced to the field of environmental epigenomics, information is provided on the important epigenetic control mechanisms and epigenetic phenomena in mammals, and the current body of literature on nutritional and environmental influences affecting the epigenome is summarized.