Dana Copot

TL;DR: This review provides the latest developments and trends in the application of fractional calculus in biomedicine and biology and addresses the properties in respiratory lung tissue, whose natural solutions arise from the midst of FC in the form of non-integer differ-integral solutions and non- integer parametric models.

TL;DR: This work revisits the pharmacokinetic models derived from classical differential equations and proposes an extension to fractional differential equations to account for tissue trapping, which modifies the predicted drug concentration profiles, which provides a better characterisation of unexplained secondary effects in patients undergoing treatment.

TL;DR: The paper gives a concise guideline as to how, when, where, and what to apply when it comes to choosing the most suitable control strategy as a function of multi-parameter objective optimization.

TL;DR: This article presents a concise overview on the recent evolution of closed-loop anesthesia delivery control systems by means of control strategies, depth of anesthesia monitors, patient modelling, safety systems, and validation in clinical trials.

TL;DR: In this paper, the authors present an open source patient simulator in Matlab/Simulink from Mathworks(R), which includes complex synergic and antagonistic interaction aspects between general anesthesia and hemodynamic stabilization variables.