D
Daniel B. Toso
Researcher at University of California, Berkeley
Publications - 8
Citations - 643
Daniel B. Toso is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Acetylation & Helicase. The author has an hindex of 7, co-authored 8 publications receiving 416 citations. Previous affiliations of Daniel B. Toso include California Institute for Quantitative Biosciences.
Papers
More filters
Journal ArticleDOI
Effects of alpha-tubulin acetylation on microtubule structure and stability.
Lisa Eshun-Wilson,Rui Zhang,Didier Portran,Maxence V. Nachury,Daniel B. Toso,Thomas Löhr,Michele Vendruscolo,Massimiliano Bonomi,James S. Fraser,Eva Nogales +9 more
TL;DR: It is proposed that the change in conformational sampling that is proposed, at a location very close to the lateral contacts site, is likely to affect microtubule stability and function.
Journal ArticleDOI
Cryo-EM structure of substrate-bound human telomerase holoenzyme
Thi Hoang Duong Nguyen,Jane Tam,Robert A. Wu,Robert A. Wu,Basil J. Greber,Basil J. Greber,Daniel B. Toso,Eva Nogales,Kathleen Collins +8 more
TL;DR: The cryo-electron microscopy structure of the substrate-bound human telomerase holoenzyme is presented, showing two flexibly RNA-tethered lobes: the catalytic core with telomersase reverse transcriptase (TERT) and conserved motifs of telomerases RNA (hTR), and an H/ACA ribonucleoprotein (RNP).
Journal ArticleDOI
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications
Vignesh Kasinath,Curtis Beck,Paul Sauer,Simon Poepsel,Jennifer Kosmatka,Marco Faini,Daniel B. Toso,Ruedi Aebersold,Ruedi Aebersold,Eva Nogales +9 more
TL;DR: In this paper, JARID2 and AEBP2 bound to a H2AK119ub1-containing nucleosome reveal a bridge helix in EZH2 that connects the SET domain, H3 tail, and nucleosomal DNA.
Posted ContentDOI
Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs
David M Kern,David M Kern,Ben Sorum,Ben Sorum,Sonali S Mali,Sonali S Mali,Christopher M Hoel,Christopher M Hoel,Savitha Sridharan,Savitha Sridharan,Jonathan P Remis,Daniel B. Toso,Abhay Kotecha,Diana M. Bautista,Diana M. Bautista,Stephen G. Brohawn,Stephen G. Brohawn +16 more
TL;DR: Electrophysiology and fluorescent ion imaging experiments show SARS-CoV-2 3a forms a functional ion channel that may promote COVID-19 pathogenesis and suggest targeting 3a could broadly treat coronavirus diseases.
Journal ArticleDOI
The complete structure of the human TFIIH core complex.
TL;DR: The structure uncovers the molecular basis of TFIIH assembly, revealing how the recruitment of XPB by p52 depends on a pseudo-symmetric dimer of homologous domains in these two proteins, and suggests a function for p62 in the regulation of XPD.