D
Diana M. Bautista
Researcher at University of California, Berkeley
Publications - 71
Citations - 16779
Diana M. Bautista is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Transient receptor potential channel & Mechanotransduction. The author has an hindex of 32, co-authored 69 publications receiving 14748 citations. Previous affiliations of Diana M. Bautista include University of California & Helen Wills Neuroscience Institute.
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Journal ArticleDOI
Cellular and Molecular Mechanisms of Pain
TL;DR: Genetic, electrophysiological, and pharmacological studies are elucidating the molecular mechanisms that underlie detection, coding, and modulation of noxious stimuli that generate pain.
Journal ArticleDOI
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Sven-Eric Jordt,Diana M. Bautista,Huai-hu Chuang,David D. McKemy,Peter M. Zygmunt,Edward D. Högestätt,Ian D. Meng,Ian D. Meng,David Julius +8 more
TL;DR: It is shown that mustard oil depolarizes a subpopulation of primary sensory neurons that are also activated by capsaicin, the pungent ingredient in chilli peppers, and by Δ9-tetrahydrocannabinol, the psychoactive component of marijuana.
Journal ArticleDOI
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.
Diana M. Bautista,Sven-Eric Jordt,Tetsuro Nikai,Pamela R. Tsuruda,Andrew J. Read,Jeannie Poblete,Ebenezer N. Yamoah,Allan I. Basbaum,David Julius +8 more
TL;DR: Using TRPA1-deficient mice, it is shown that this channel is the sole target through which mustard oil and garlic activate primary afferent nociceptors to produce inflammatory pain.
Journal ArticleDOI
The menthol receptor TRPM8 is the principal detector of environmental cold
Diana M. Bautista,Jan Siemens,Joshua M. Glazer,Pamela R. Tsuruda,Allan I. Basbaum,Cheryl L. Stucky,Sven-Eric Jordt,David Julius +7 more
TL;DR: It is shown that cultured sensory neurons and intact sensory nerve fibres from TRPM8-deficient mice exhibit profoundly diminished responses to cold, validating the hypothesis that TRP channels are the principal sensors of thermal stimuli in the peripheral nervous system.
Journal ArticleDOI
TRPA1 mediates formalin-induced pain
Colleen Mcnamara,Josh Mandel-Brehm,Diana M. Bautista,Jan Siemens,Kari L. Deranian,Michael Zhao,Neil Hayward,Jayhong A. Chong,David Julius,Magdalene M. Moran,Christopher M. Fanger +10 more
TL;DR: It is shown that TRPA1 is the principal site of formalin's pain-producing action in vivo, and that activation of this excitatory channel underlies the physiological and behavioral responses associated with this model of pain hypersensitivity.