D
Daniel C. Pevear
Researcher at ViroPharma
Publications - 38
Citations - 3309
Daniel C. Pevear is an academic researcher from ViroPharma. The author has contributed to research in topics: Rhinovirus & Virus. The author has an hindex of 24, co-authored 34 publications receiving 3028 citations. Previous affiliations of Daniel C. Pevear include United States Army Medical Research Institute of Infectious Diseases & Purdue University.
Papers
More filters
Journal ArticleDOI
An Orally Bioavailable Antipoxvirus Compound (ST-246) Inhibits Extracellular Virus Formation and Protects Mice from Lethal Orthopoxvirus Challenge
Guang Yang,Daniel C. Pevear,Marc H. Davies,Marc S. Collett,Thomas R. Bailey,Susan Rippen,Barone Linda,Christopher J. Burns,Gerry Rhodes,Sanjeev Tohan,John W. Huggins,Robert O. Baker,R. L. Mark Buller,Erin Touchette,Kem Waller,Jill Schriewer,Johan Neyts,Erik Declercq,Kevin F. Jones,Dennis E. Hruby,Robert Jordan +20 more
TL;DR: Results validate F13L as an antiviral target and demonstrate that an inhibitor of extracellular virus formation can protect mice from orthopoxvirus-induced disease.
Journal ArticleDOI
Activity of Pleconaril against Enteroviruses
TL;DR: Pleconaril represents a promising new drug candidate for potential use in the treatment of human enteroviral infections and dramatically reduced virus levels in target tissues of coxsackievirus serotype B3 strain M-infected animals.
Journal ArticleDOI
The structure of coxsackievirus B3 at 3.5 å resolution
Jodi K. Muckelbauer,Marcia J. Kremer,Iwona Minor,Guy D. Diana,Frank J. Dutko,James M. Groarke,Daniel C. Pevear,Michael G. Rossmann +7 more
TL;DR: The canyon and twofold depression, major surface depressions, are predicted to be the primary and secondary receptor-binding sites on CVB3, respectively and the ions located on the icosahedral threefold and fivefold axes together with the pocket factor may contribute to the pH stability of the coxsackieviruses.
Journal ArticleDOI
Efficacy and Safety of Oral Pleconaril for Treatment of Colds Due to Picornaviruses in Adults: Results of 2 Double-Blind, Randomized, Placebo-Controlled Trials
Frederick G. Hayden,Frederick G. Hayden,Darrell T. Herrington,Teresa L. Coats,Kenneth Kim,Ellen C. Cooper,Stephen Villano,Siyu Liu,Spencer Hudson,Daniel C. Pevear,Marc S. Collett,Mark A McKinlay +11 more
TL;DR: Early pleconaril treatment was well tolerated and significantly reduced the duration and severity of colds due to picornaviruses in adults, and was associated with a higher incidence of nausea and diarrhea, and with small increases in mean serum cholesterol levels and platelet counts, compared with baseline measurements.
Journal ArticleDOI
The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation.
Kyung H. Choi,James M. Groarke,James M. Groarke,Dorothy C. Young,Richard J. Kuhn,Janet L. Smith,Daniel C. Pevear,Michael G. Rossmann +7 more
TL;DR: The structure of BVDV polymerase complexed with GTP, which is required for de novo (primer-independent) initiation, shows that GTP binds adjacent to the initiation NTP, suggesting that the GTP mimics aigial RNA product.