Jill Schriewer

TL;DR: It is demonstrated that a West Nile virus mutant that lacks 2′-O MTase activity was attenuated in wild-type primary cells and mice but was pathogenic in the absence of type I interferon (IFN) signalling, and suggested an evolutionary explanation for 2-O methylation of cellular mRNA: to distinguish self from non-self RNA.

TL;DR: Results validate F13L as an antiviral target and demonstrate that an inhibitor of extracellular virus formation can protect mice from orthopoxvirus-induced disease.

TL;DR: Congo basin MPXV-ZAI-V79 is more virulent for cynomolgus monkeys as compared to presumed West African MPxV-COP-58, which may explain the lack of case-fatalities in the U.S. 2003 monkeypox outbreak.

TL;DR: Octadecyloxyethyl-CDV appeared to be the most potent CDV analog as a dose regimen started 4 h following challenge completely blocked virus replication in spleen and liver, and protected 100% of A/NCR mice, although oral, unmodified CDV was inactive.

TL;DR: The data indicate that open reading frames 7a and 7b contribute to but are not solely responsible for the apoptosis seen in SARS-CoV-infected cells, indicating that the gene 7 products do contribute to virus-induced apoptosis.