D
Daniel J. Siebert
Publications - 4
Citations - 1188
Daniel J. Siebert is an academic researcher. The author has contributed to research in topics: κ-opioid receptor & Salvinorin A. The author has an hindex of 4, co-authored 4 publications receiving 1122 citations.
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Journal ArticleDOI
Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist
Bryan L. Roth,Karen Baner,Richard B. Westkaemper,Daniel J. Siebert,Kenner C. Rice,Seanna Steinberg,Paul Ernsberger,Richard B. Rothman +7 more
TL;DR: Salvinorin A is the first naturally occurring nonnitrogenous opioid-receptor subtype-selective agonist for κ opioid receptors and may represent novel psychotherapeutic compounds for diseases manifested by perceptual distortions (e.g., schizophrenia, dementia, and bipolar disorders).
Journal ArticleDOI
Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.
Charles Chavkin,Sumit Sud,Wenzhen Jin,Jeremy Stewart,Jordan K. Zjawiony,Daniel J. Siebert,Beth Ann Toth,Sandra J. Hufeisen,Bryan L. Roth +8 more
TL;DR: Salvinorin A was found to be a full agonist, being significantly more efficacious than (trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl] benzeneacetamide methane-sulfonate hydrate (U69593) and similar in efficacy to dynorphin A (the naturally occurring peptide ligand for κ-opioid receptors).
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Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo.
Yulin Wang,Kang Tang,Saadet Inan,Daniel J. Siebert,Ulrike Holzgrabe,David Y.W. Lee,Peng Huang,Jian-Guo Li,Alan Cowan,Lee-Yuan Liu-Chen +9 more
TL;DR: In vitro pharmacological activities on receptors expressed in Chinese hamster ovary cells and in vivo antiscratch and antinociceptive activities in mice are investigated and salvinorin A, TRK-820, and 3FLB caused internalization of the human KOR in a dose-dependent manner.
Journal ArticleDOI
Antinociceptive and Hypothermic Effects of Salvinorin A Are Abolished in a Novel Strain of κ-Opioid Receptor-1 Knockout Mice
Michael Ansonoff,Jiwen Zhang,Jiwen Zhang,Traci A. Czyzyk,Richard B. Rothman,Jeremy Stewart,Heng Xu,Jordan Zjwiony,Jordan Zjwiony,Daniel J. Siebert,Feng Yang,Bryan L. Roth,John E. Pintar +12 more
TL;DR: It is demonstrated that salvinorin A is the active component of S. divinorum, selective for κ1-opioid receptors, and that salvinegorin A and specific structurally related analogs produce behavioral effects that require the κ-opIOid receptor.