Paul Ernsberger

TL;DR: This work began with 65,000 ligands annotated into sets for hundreds of drug targets, and found that methadone, emetine and loperamide (Imodium) may antagonize muscarinic M3, α2 adrenergic and neurokinin NK2 receptors, respectively.

TL;DR: It is recommended that the next generation of atypical antipsychotic drugs be screened to avoid H1-histamine receptors, which are known to induce weight gain with chronic use.

TL;DR: Salvinorin A is the first naturally occurring nonnitrogenous opioid-receptor subtype-selective agonist for κ opioid receptors and may represent novel psychotherapeutic compounds for diseases manifested by perceptual distortions (e.g., schizophrenia, dementia, and bipolar disorders).

TL;DR: This article evaluates four central claims made by those calling for intensifying the war on fat: that obesity is an epidemic; that overweight and obesity are major contributors to mortality; that higher than average adiposity is pathological and a primary direct cause of disease; and that significant long-term weight loss is both medically beneficial and a practical goal.

TL;DR: Describing binding sites labeled by [3H]p-aminoclonidine in bovine brain membranes prepared from the ventrolateral medulla found that these sites may mediate, in part, the hypotensive action of clonidine and other imidazole compounds in the ventral medulla.