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Daniel K. Hsu
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 9
Citations - 2399
Daniel K. Hsu is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Macrophage & Monocyte. The author has an hindex of 8, co-authored 9 publications receiving 2275 citations. Previous affiliations of Daniel K. Hsu include Scripps Research Institute & University of Nebraska–Lincoln.
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Journal ArticleDOI
Expression of galectin-3 modulates T-cell growth and apoptosis
TL;DR: Galectin-3 is a regulator of cell growth and apoptosis and it may function through a cell death inhibition pathway that involves Bcl-2, a well-characterized suppressor of apoptosis.
Journal ArticleDOI
Human Galectin-3 Is a Novel Chemoattractant for Monocytes and Macrophages
Hideki Sano,Daniel K. Hsu,Lan Yu,John R. Apgar,Ichiro Kuwabara,Tohru Yamanaka,Mitsuomi Hirashima,Fu-Tong Liu +7 more
TL;DR: The results indicate that galectin-3 is a novel chemoattractant for monocytes and macrophages and suggest that the effect is mediated at least in part through a PTX-sensitive (G protein-coupled) pathway.
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Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses.
Daniel K. Hsu,Ri Yao Yang,Zhixing Pan,Lan Yu,Daniel R. Salomon,Wai-Ping Fung-Leung,Fu-Tong Liu +6 more
TL;DR: It was found that peritoneal macrophages from gal3(-/-) mice were more prone to undergo apoptosis than those from Gal3(+/+) mice when treated with apoptotic stimuli, suggesting that expression of galectin-3 in inflammatory cells may lead to longer cell survival, thus prolonging inflammation.
Journal Article
Expression and function of galectin-3, a beta-galactoside-binding lectin, in human monocytes and macrophages.
TL;DR: Galectin-3 was found to be expressed in normal human peripheral blood monocytes and its level increases dramatically as human monocytes differentiate into macrophages upon culturing in vitro as mentioned in this paper.
Journal ArticleDOI
Cell cycle regulation by galectin-12, a new member of the galectin superfamily.
TL;DR: It is concluded that galectin-12 is a novel regulator of cellular homeostasis, which contains two domains that are homologous to the galECTin CRD.