Cell cycle regulation by galectin-12, a new member of the galectin superfamily.
TLDR
It is concluded that galectin-12 is a novel regulator of cellular homeostasis, which contains two domains that are homologous to the galECTin CRD.About:
This article is published in Journal of Biological Chemistry.The article was published on 2001-06-08 and is currently open access. It has received 135 citations till now. The article focuses on the topics: Galectin & Cell Cycle Protein.read more
Citations
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Galectins as modulators of tumour progression
TL;DR: Current research indicates that galectins have important roles in cancer; they contribute to neoplastic transformation, tumour cell survival, angiogenesis and tumour metastasis, and might have a key role helping tumours to escape immune surveillance.
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Galectins: structure, function and therapeutic potential.
TL;DR: Current research indicates that galectins play important roles in diverse physiological and pathological processes, including immune and inflammatory responses, tumour development and progression, neural degeneration, atherosclerosis, diabetes, and wound repair, and may be a therapeutic target or employed as therapeutic agents for inflammatory diseases, cancers and several other diseases.
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Intracellular functions of galectins
TL;DR: This review summarizes the intracellular activities displayed by several galectins and discusses the possible underlying mechanisms.
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Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?
Gabriel A. Rabinovich,Linda G. Baum,Nicola Tinari,Roberto Paganelli,Clara Natoli,Fu-Tong Liu,Stefano Iacobelli +6 more
TL;DR: The current wealth of new information promises a future scenario in which individual members of the galectin family or their ligands will be used as powerful anti-inflammatory mediators and selective modulators of the immune response.
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Galectinomics: finding themes in complexity.
TL;DR: Although the identification of many novel galectin relatives in widely divergent organisms has added significantly to the size and complexity of this intriguing protein family, several common themes arise, which suggest promising new research targets.
References
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Clustal w: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
TL;DR: The sensitivity of the commonly used progressive multiple sequence alignment method has been greatly improved and modifications are incorporated into a new program, CLUSTAL W, which is freely available.
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p53, the Cellular Gatekeeper for Growth and Division
TL;DR: The author regrets the lack of citations for many important observations mentioned in the text, but their omission is made necessary by restrictions in the preparation of review manuscripts.
Book
Current protocols in immunology
TL;DR: Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, and animal models of autoimmune and inflammatory diseases.
Journal ArticleDOI
Cancer Cell Cycles
TL;DR: Genetic alterations affecting p16INK4a and cyclin D1, proteins that govern phosphorylation of the retinoblastoma protein and control exit from the G1 phase of the cell cycle, are so frequent in human cancers that inactivation of this pathway may well be necessary for tumor development.
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