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Daniel Lajeunesse
Researcher at Université de Montréal
Publications - 78
Citations - 6588
Daniel Lajeunesse is an academic researcher from Université de Montréal. The author has contributed to research in topics: Osteoblast & Osteocalcin. The author has an hindex of 38, co-authored 78 publications receiving 5847 citations. Previous affiliations of Daniel Lajeunesse include National Institutes of Health & Johns Hopkins University.
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Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
TL;DR: The current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA is discussed and the potential of anticytokine therapy in the treatment of this disease is addressed.
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Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs.
TL;DR: Dual 5-LOX/COX inhibitors act by blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin formation, which avoids some of the disadvantages of selective COX-2 inhibitors and spares the gatrointestinal mucosa.
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Osteoblast‐like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: Possible role in subchondral bone sclerosis
TL;DR: Ex vivo and in vitro results indicate similar altered activities of OA osteoblast-like cells as compared with normal cells, suggesting that an altered phenotype of subchondral osteoblasts may be a contributing factor in human OA.
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Can altered production of interleukin-1β, interleukin-6, transforming growth factor-β and prostaglandin E2 by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients
Frédéric Massicotte,Daniel Lajeunesse,Mohamed Benderdour,J.-P. Pelletier,George Hilal,Nicolas Duval,Johanne Martel-Pelletier +6 more
TL;DR: IL-6 and PGE(2) production by subchondral Ob can discriminate two subgroups of osteoarthritic patients that cannot otherwise be separated by their expression of cell markers, and that endogenous PGE (2) levels influence IL-6 synthesis in osteoartritic Ob.
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Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling.
Daniel Lajeunesse,Pascal Reboul +1 more
TL;DR: New findings highlighting the concept of cross-talk between subchondral bone tissue and articular cartilage that may be crucial for the initiation and/or progression of osteoarthritis have an immediate implication for research because new tools need to be developed to study the subchONDral bone–cartilage functional unit.