Daniel M. Koller

TL;DR: High-speed spectral domain OCT was used for the characterization of pharmaceutical tablet coatings, sampled at different stages of an industrial drum spray coating process, comprising tablets with a coating thickness ranging from uncoated to a target coating thickness of about 70 μm.

TL;DR: In this paper, FT-NIR spectroscopy with a fiber optical reflection probe was applied as a process analytical technology tool for the continuous quantitative in-line monitoring of pharmaceutical powder mixing processes in a bladed mixer.

TL;DR: A multivariate supervisory quality control strategy was developed for the process to monitor the hot melt extrusion process on the basis of principal component analysis (PCA) of the NIR spectra.

TL;DR: The data reveal that oxidized phospholipids induce apoptosis in cultured macrophages and the mechanism of lipid toxicity, however, largely depends on the structural features of the oxidized sn- 2 chain.

TL;DR: This experimental study investigates the mixing behavior of acetyl salicylic acid as an API and α-lactose monohydrate as an excipient for different filling orders and filling levels in a blender to detect good and poor mixing positions inside the blender that are affected by convective and diffusive mixing.