Daniel Marrama

TL;DR: Using HLA class I and II predicted peptide ‘megapools’, circulating SARS-CoV-2−specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 convalescent patients, respectively, suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS.

TL;DR: This paper performed a sequence identity comparison between SARS-CoV-2 spike protein-derived peptides and myocarditis-associated antigens and found no significant enrichment in the frequency of spike derived peptides similar to auto-antigens as compared to several controls.

TL;DR: The data support a contribution of molecular mimicry in COVID-19 ITP autoimmunity and offer avenues for in vitro diagnostic assay development.

TL;DR: 6 immunodominant epitopes (APOB6) that triggered robust CD4+ T activation in most donors were discovered and validated and the immune response to these APOB epitopes correlated with coronary artery disease severity.

TL;DR: This work hypothesized that human APOB may contain discrete immunodominant CD4+ T-cell epitopes that trigger atherosclerosis-related autoimmune responses in donors with diverse HLA alleles and discovered and validated 6 immunoddomant, HLA-II-restricted APOB epitopes.