D
Daniel Sinnecker
Researcher at Technische Universität München
Publications - 65
Citations - 3025
Daniel Sinnecker is an academic researcher from Technische Universität München. The author has contributed to research in topics: Induced pluripotent stem cell & Myocardial infarction. The author has an hindex of 19, co-authored 60 publications receiving 2567 citations. Previous affiliations of Daniel Sinnecker include Free University of Berlin & Ludwig Maximilian University of Munich.
Papers
More filters
Journal ArticleDOI
Patient-specific induced pluripotent stem-cell models for long-QT syndrome.
Alessandra Moretti,Milena Bellin,Andrea Welling,Christian Jung,Jason T. Lam,Lorenz Bott-Flügel,Tatjana Dorn,Alexander Goedel,Christian Höhnke,Franz Hofmann,Melchior Seyfarth,Daniel Sinnecker,Albert Schömig,Karl-Ludwig Laugwitz +13 more
TL;DR: It was shown that myocytes derived from patients with long-QT syndrome type 1 had an increased susceptibility to catecholamine-induced tachyarrhythmia and that beta-blockade attenuated this phenotype.
Journal ArticleDOI
Dantrolene rescues arrhythmogenic RYR2 defect in a patient‐specific stem cell model of catecholaminergic polymorphic ventricular tachycardia
Christian B. Jung,Alessandra Moretti,Michael Mederos y Schnitzler,Laura Iop,Ursula Storch,Milena Bellin,Tatjana Dorn,Sandra Ruppenthal,Sarah Pfeiffer,Alexander Goedel,Ralf J. Dirschinger,Melchior Seyfarth,Jason T. Lam,Daniel Sinnecker,Thomas Gudermann,Peter Lipp,Karl-Ludwig Laugwitz +16 more
TL;DR: The generation of induced pluripotent stem cells (iPSCs) from a CPVT patient carrying a novel RYR2 S406L mutation provides a new in vitro model to study the pathogenesis of human cardiac arrhythmias and develop novel therapies for CPVT.
Journal ArticleDOI
Reversible photobleaching of enhanced green fluorescent proteins.
TL;DR: It is shown that experimental settings commonly used in these imaging experiments may induce an as yet uncharacterized reversible photobleaching of fluorescent proteins, which is more pronounced at acidic pH.
Journal ArticleDOI
Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy
Alessandra Moretti,LM Fonteyne,Florian Giesert,Petra Hoppmann,A. B. Meier,Tarik Bozoglu,Andrea Baehr,Christine M. Schneider,Daniel Sinnecker,Katharina Klett,Thomas Fröhlich,F. Abdel Rahman,T. Haufe,Shicheng Sun,Victoria Jurisch,Barbara Kessler,Rabea Hinkel,Ralf J. Dirschinger,Eimo Martens,C. Jilek,Alexander Graf,Stefan Krebs,Gianluca Santamaria,Mayuko Kurome,V. Zakhartchenko,B. Campbell,K. Voelse,Anja Wolf,Tilman Ziegler,S. Reichert,Seungmin Lee,Florian Flenkenthaler,Tatjana Dorn,Irmela Jeremias,Helmut Blum,Andreas Dendorfer,Angelika Schnieke,S Krause,M. C. Walter,Nikolai Klymiuk,Karl-Ludwig Laugwitz,Eckhard Wolf,Wolfgang Wurst,Wolfgang Wurst,Christian Kupatt +44 more
TL;DR: CRISPR–Cas9-mediated gene editing restores dystrophin expression in both pig and human induced pluripotent stem cell models of Duchenne muscular dystrophy, with beneficial effects on skeletal muscle and cardiac function.
Journal ArticleDOI
Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes
Marcella Rocchetti,Luca Sala,Lisa Dreizehnter,Lia Crotti,Daniel Sinnecker,Manuela Mura,Luna Simona Pane,Claudia Altomare,Eleonora Torre,Gaspare Mostacciuolo,Stefano Severi,Alberto Porta,Gaetano M. De Ferrari,Alfred L. George,Peter J. Schwartz,Massimiliano Gnecchi,Massimiliano Gnecchi,Alessandra Moretti,Antonio Zaza +18 more
TL;DR: The main functional derangement in CALM1-F142L was prolonged repolarization with altered rate-dependency and sensitivity to &bgr;-adrenergic stimulation, a finding well reproduced by using a recent hiPSC-CM action potential model.