M
Michael Mederos y Schnitzler
Researcher at Ludwig Maximilian University of Munich
Publications - 42
Citations - 4138
Michael Mederos y Schnitzler is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Transient receptor potential channel & TRPC. The author has an hindex of 28, co-authored 41 publications receiving 3665 citations. Previous affiliations of Michael Mederos y Schnitzler include University of Marburg.
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Journal ArticleDOI
Increased Vascular Smooth Muscle Contractility in TRPC6 −/− Mice
Alexander Dietrich,Michael Mederos y Schnitzler,Maik Gollasch,Volkmar Gross,Ursula Storch,Galyna Dubrovska,Michael Obst,Eda Yildirim,Birgit Salanova,Hermann Kalwa,Kirill Essin,Olaf Pinkenburg,Friedrich C. Luft,Thomas Gudermann,Lutz Birnbaumer +14 more
TL;DR: It is implied that constitutively active TRPC3-type channels, which are up-regulated in TRPC6-deficient smooth muscle cells, are not able to functionally replace TRPC 6, which has distinct nonredundant roles in the control of vascular smooth muscle tone.
Journal ArticleDOI
Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia
Vladimir Chubanov,Siegfried Waldegger,Michael Mederos y Schnitzler,Helga Vitzthum,Martin Sassen,Hannsjörg W. Seyberth,Martin Konrad,Thomas Gudermann +7 more
TL;DR: The naturally occurring S141L TRPM 6 missense mutation abrogated the oligomeric assembly of TRPM6, thus providing a cell biological explanation for the human disease.
Journal ArticleDOI
Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction
Michael Mederos y Schnitzler,Ursula Storch,Simone Meibers,Pascal Nurwakagari,Andreas Breit,Kirill Essin,Maik Gollasch,Thomas Gudermann,Thomas Gudermann +8 more
TL;DR: It is shown that membrane stretch does not primarily gate mechanosensitive transient receptor potential (TRP) ion channels, but leads to agonist‐independent activation of Gq/11‐coupled receptors, which subsequently signal to TRPC channels in a G protein‐ and phospholipase C‐dependent manner.
Journal ArticleDOI
Dantrolene rescues arrhythmogenic RYR2 defect in a patient‐specific stem cell model of catecholaminergic polymorphic ventricular tachycardia
Christian B. Jung,Alessandra Moretti,Michael Mederos y Schnitzler,Laura Iop,Ursula Storch,Milena Bellin,Tatjana Dorn,Sandra Ruppenthal,Sarah Pfeiffer,Alexander Goedel,Ralf J. Dirschinger,Melchior Seyfarth,Jason T. Lam,Daniel Sinnecker,Thomas Gudermann,Peter Lipp,Karl-Ludwig Laugwitz +16 more
TL;DR: The generation of induced pluripotent stem cells (iPSCs) from a CPVT patient carrying a novel RYR2 S406L mutation provides a new in vitro model to study the pathogenesis of human cardiac arrhythmias and develop novel therapies for CPVT.
Journal ArticleDOI
Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange.
Norbert Weissmann,Alexander Dietrich,Beate Fuchs,Hermann Kalwa,Mahmut Ay,Rio Dumitrascu,Andrea Olschewski,Ursula Storch,Michael Mederos y Schnitzler,Hossein Ardeschir Ghofrani,Ralph T. Schermuly,Olaf Pinkenburg,Werner Seeger,Friedrich Grimminger,Thomas Gudermann +14 more
TL;DR: It is concluded that TRPC6 plays a unique and indispensable role in acute hypoxic pulmonary vasoconstriction and Manipulation of TRPC 6 function may offer a therapeutic strategy for the control of pulmonary hemodynamics and gas exchange.