Christine M. Schneider

TL;DR: CRISPR–Cas9-mediated gene editing restores dystrophin expression in both pig and human induced pluripotent stem cell models of Duchenne muscular dystrophy, with beneficial effects on skeletal muscle and cardiac function.

TL;DR: By combining a genetically encoded membrane voltage sensor with promoters that drive its expression in the major subtypes of hiPSC-CMs, a convenient system for disease modelling and drug evaluation in the relevant cell type has the potential to advance the emerging utility of hi PSCs in cardiovascular medicine.

TL;DR: In this article, complex molecular programs in specific cell lineages govern human heart development, and Hypoplastic left heart syndrome (HLHS) is the most common and severe manifestation within the spectrogram.

TL;DR: In this paper, the authors identify perturbations in gene programs controlling ventricular muscle lineage development in Hypoplastic Left Heart Syndrome (HLHS) and demonstrate that despite genetic heterogeneity in HLHS, many mutations converge on sequential cellular processes primarily driving cardiac myogenesis, suggesting novel therapeutic approaches.

TL;DR: In this article, the authors developed a new approach for the generation of cardiac tissues based on biomimetic stimulation under application of continuously increasing stretch, which can simulate the conditions of postnatal myocardial growth.