D
Daniel T. Grimes
Researcher at University of Oregon
Publications - 22
Citations - 1048
Daniel T. Grimes is an academic researcher from University of Oregon. The author has contributed to research in topics: Cilium & Zebrafish. The author has an hindex of 13, co-authored 19 publications receiving 808 citations. Previous affiliations of Daniel T. Grimes include University of Washington & Princeton University.
Papers
More filters
Journal ArticleDOI
Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature
Daniel T. Grimes,Curtis W. Boswell,Nicholas F.C. Morante,R. M. Henkelman,Rebecca D. Burdine,Brian Ciruna +5 more
TL;DR: It is shown that ptk7 mutant zebrafish, a faithful developmental model of IS, exhibit defects in ependymal cell cilia development and cerebrospinal fluid (CSF) flow, and a critical role for cilia-driven CSF flow in spine development is indicated, which implicate irregularities inCSF flow as an underlying biological cause of IS and suggest that noninvasive therapeutic intervention may prevent severe scoliosis.
Journal ArticleDOI
Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2
Sarah Field,Kerry-Lyn Riley,Daniel T. Grimes,Helen Hilton,Michelle Simon,Nicola Powles-Glover,Pam Siggers,Debora Bogani,Andy Greenfield,Dominic P. Norris +9 more
TL;DR: Cell biological analysis and biochemical experiments demonstrate that Pkd1l1 is the elusive PKd2 binding partner required for L-R patterning and support the two-cilia hypothesis, which has been identified as a crucial component of L- R patterning in mouse.
Journal ArticleDOI
Left–Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis
TL;DR: Proper execution of asymmetric organogenesis is critical to health, making furthering the understanding of L-R development an important concern.
Journal ArticleDOI
Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway
Victoria L. Patterson,Christine Damrau,Anju Paudyal,Benjamin Reeve,Daniel T. Grimes,Michelle Stewart,Debbie Williams,Pam Siggers,Andy Greenfield,Jennifer N. Murdoch +9 more
TL;DR: It is demonstrated that Tulp3 acts genetically downstream of Shh and Smoothened in neural tube patterning and exhibits a genetic interaction with Gli3 in limb development and transcriptional regulation of other negative regulators (Rab23, Fkbp8, Thm1, Sufu and PKA) is not affected.
Journal ArticleDOI
Mouse models of ciliopathies: the state of the art
TL;DR: Current mouse models of a core set of ciliopathies, their utility and future prospects are reviewed.