J
Jennifer N. Murdoch
Researcher at Royal Holloway, University of London
Publications - 47
Citations - 5417
Jennifer N. Murdoch is an academic researcher from Royal Holloway, University of London. The author has contributed to research in topics: Neural tube & Neurulation. The author has an hindex of 29, co-authored 47 publications receiving 5073 citations. Previous affiliations of Jennifer N. Murdoch include University College London & Medical Research Council.
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Journal ArticleDOI
The genetic basis of mammalian neurulation
TL;DR: More than 80 mutant mouse genes disrupt neurulation and allow an in-depth analysis of the underlying developmental mechanisms, including the planar cell-polarity pathway and the sonic hedgehog signalling pathway that regulates neural plate bending.
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Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse.
John A. Curtin,Elizabeth Quint,Vicky Tsipouri,Ruth M. Arkell,Bruce Cattanach,Andrew J. Copp,Deborah J. Henderson,Nigel K. Spurr,Philip Stanier,Elizabeth M. C. Fisher,Patrick M. Nolan,Karen P. Steel,Steve D.M. Brown,Ian C. Gray,Jennifer N. Murdoch +14 more
TL;DR: The identification of mouse mutants of Celsr1 provides the first evidence for the function of the CelsR family in planar cell polarity in mammals and further supports the involvement of a planarcell polarity pathway in vertebrate neurulation.
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Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates
Alison Ross,Helen May-Simera,Erica R. Eichers,Masatake Kai,Josephine Hill,Daniel J. Jagger,Carmen C. Leitch,J. Paul Chapple,Peter M. G. Munro,Shannon Fisher,Perciliz L. Tan,Helen M. Phillips,Michel R. Leroux,Deborah J. Henderson,Jennifer N. Murdoch,Andrew J. Copp,Marie-Madeleine Eliot,James R. Lupski,David T. Kemp,Hélène Dollfus,Masazumi Tada,Nicholas Katsanis,Andrew Forge,Philip L. Beales +23 more
TL;DR: It is shown that mice with mutations in genes involved in Bardet-Biedl syndrome share phenotypes with PCP mutants including open eyelids, neural tube defects and disrupted cochlear stereociliary bundles, and that Vangl2 localizes to the basal body and axoneme of ciliated cells, suggesting that cilia are intrinsically involved in PCP processes.
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Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification
TL;DR: The findings suggest that the mutual interaction between Lpp1 and Shh may define the lateral boundary of floor plate differentiation, which disrupts neurulation by permitting more extensive floor plate induction by Shh, thereby inhibiting midline bending of the neural plate during initiation of neurulation.
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Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse
Jennifer N. Murdoch,Deborah J. Henderson,Kit Doudney,Carles Gaston-Massuet,Helen M. Phillips,C Paternotte,Ruth M. Arkell,Philip Stanier,Andrew J. Copp +8 more
TL;DR: The identification of the Crc gene further defines the nature of the genetic pathway required for the initiation of neural tube closure and provides an important new candidate that may be implicated in the aetiology of human NTDs.