Daniel Verschueren

TL;DR: Solid-state nanopores can be used to directly observe individual knots in both linear and circular single DNA molecules of arbitrary length and it is found that the knotting occurrence rises with the length of the DNA molecule, consistent with a constant knotting probability per unit length.

TL;DR: A mechanism based on plasmon-induced local heating and thermophoresis as explanation of the observations is proposed and provides a means to utilize the excellent spatiotemporal resolution of DNA interrogations with nanopores in LiCl buffers, which is known to suffer from low event rates.

TL;DR: It is demonstrated that translocations of single DNA molecules can be optically detected in the transmitted light intensity through an inverted-bowtie plasmonic nanopore, and this label-free optical detection scheme offers opportunities to probe native DNA–protein interactions at physiological conditions.

TL;DR: The integration of two single-molecule sensors, a plasmonic nanoantenna and solid-state nanopore, creates independent control handles at the single-Molecule level—the optical trapping force and electrophoretic force—which provides augmented control over single molecules.

TL;DR: The electric field applied to the nanopore can actively drive biomolecules away from the hotspot, preventing molecules to permanently bind to the gold sensor surface and allowing efficient reuse of the sensor, significantly outperforms conventional plasmon resonance sensors and provides great opportunities for high-throughput optical single-molecule-sensing assays.