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Daniela Caronia
Researcher at Mario Negri Institute for Pharmacological Research
Publications - 8
Citations - 854
Daniela Caronia is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: Capecitabine & Nucleotide excision repair. The author has an hindex of 6, co-authored 8 publications receiving 789 citations.
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Journal ArticleDOI
Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma
Iñaki Comino-Méndez,Francisco Javier Gracia-Aznarez,Francesca Schiavi,Iñigo Landa,Luis J Leandro-García,Rocío Letón,Emiliano Honrado,Rocío Ramos-Medina,Daniela Caronia,Guillermo Pita,Álvaro Gómez-Graña,Aguirre A. de Cubas,Lucía Inglada-Pérez,Agnieszka Maliszewska,Elisa Taschin,Sara Bobisse,Giuseppe Pica,Paola Loli,Rafael Hernández-Lavado,José Ángel Díaz,Mercedes Gómez-Morales,Anna González-Neira,Giovanna Roncador,Cristina Rodríguez-Antona,Javier Benitez,Massimo Mannelli,Giuseppe Opocher,Mercedes Robledo,Alberto Cascón +28 more
TL;DR: The involvement of the MYC-MAX-MXD1 network in the development and progression of neural crest cell tumors is supported and the lack of functional MAX in rat PCC (PC12) cells is supported, which suggests that loss of MAX function is correlated with metastatic potential.
Journal ArticleDOI
Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients
Daniela Caronia,Ana Patiño-García,Roger L. Milne,Marta Zalacain-Diez,G Pita,María R Alonso,Leticia Tais Moreno,Luis Sierrasesúmaga-Ariznabarreta,Javier Benítez,Anna González-Neira +9 more
TL;DR: This is the first pharmacogenetic study focused on osteosarcoma treatment providing evidence that polymorphic variants in DNA repair genes could be useful predictors of response to cisplatin chemotherapy in osteosARcoma patients.
Journal ArticleDOI
A polymorphism in the cytidine deaminase promoter predicts severe capecitabine-induced hand-foot syndrome
Daniela Caronia,Miguel Martin,Javier Sastre,Julio de la Torre,José A. García-Sáenz,María R Alonso,Leticia T. Moreno,Guillermo Pita,Eduardo Díaz-Rubio,Javier Benitez,Anna González-Neira +10 more
TL;DR: The deleted allele of rs3215400 shows an increased allele-specific expression and is significantly associated with an increased risk of capecitabine-induced HFS, suggesting that this insertion might create a binding site for the transcriptional regulator E2F.
Journal ArticleDOI
Effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy: a pharmacogenetic study.
Daniela Caronia,Ana Patiño-García,Antonio Pérez-Martínez,Guillermo Pita,Leticia Tais Moreno,Marta Zalacain-Diez,Blanca Molina,Isabel Colmenero,Luis Sierrasesúmaga,Javier Benitez,Anna González-Neira +10 more
TL;DR: If these associations are independently validated, these variants could be used as genetic predictors of clinical outcome in the treatment of osteosarcoma, helping in the design of individualized therapy.
Journal ArticleDOI
Vascular endothelial growth factor stimulates organ-specific host matrix metalloproteinase-9 expression and ovarian cancer invasion.
Dorina Belotti,Catia Calcagno,Angela Garofalo,Daniela Caronia,E. Riccardi,Raffaella Giavazzi,Giulia Taraboletti +6 more
TL;DR: Findings point to a complex cross-talk between VEGF and MMPs in the progression of ovarian tumor and suggest the possibility of using V EGF inhibitors to affect MMP-dependent tumor invasion.