Daniela Gallo

TL;DR: It is indicated that overexpression of class III beta-tubulin is the most prominent mechanism of paclitaxel resistance in ovarian cancer.

TL;DR: SOYSELECT may be a safe and efficacious therapy for relief of hot flushes in women who refuse or have contraindications for hormone replacement therapy.

TL;DR: CD133+ cells were capable of initiating tumor formation and recapitulating the phenotype of the original tumor when serially transplanted into NOD/SCID mice, and might represent a valuable tool to identify cells with cancer stem cell characteristics.

TL;DR: It is revealed here that paclitaxel directly targets Bcl-2 in the loop domain, thereby facilitating the initiation of apoptosis, and could help in the development of novel anticancer agents with nontaxane skeleton as well as in identifying the clinical subsets responsive to pac litaxel-based therapy.

TL;DR: It is demonstrated that Bcl-2 is an additional intracellular target of taxanes and that its down-regulation is involved in taxane resistance.