U
Ugo Testa
Researcher at Istituto Superiore di Sanità
Publications - 413
Citations - 19499
Ugo Testa is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Haematopoiesis & Cellular differentiation. The author has an hindex of 70, co-authored 398 publications receiving 18258 citations. Previous affiliations of Ugo Testa include Thomas Jefferson University & University of Perugia.
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Journal ArticleDOI
The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells
Francesco Grignani,Pier Francesco Ferrucci,Ugo Testa,Giampaolo Talamo,Marta Fagioli,Myriam Alcalay,Amedea Mencarelli,Fausto Grignani,Cesare Peschle,Cesare Peschle,Ildo Nicoletti,Pier Giuseppe Pelicci +11 more
TL;DR: Expressing the PML-RAR alpha protein in U937 myeloid precursor cells showed that they lost the capacity to differentiate under the action of different stimuli, acquired enhanced sensitivity to retinoic acid, and exhibited a higher growth rate consequent to diminished apoptotic cell death.
Journal ArticleDOI
MicroRNAs 17-5p–20a–106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation
Laura Fontana,Elvira Pelosi,Paolo Greco,Serena Racanicchi,Ugo Testa,Francesca Liuzzi,Carlo M. Croce,Ercole Brunetti,Francesco Grignani,Cesare Peschle,Cesare Peschle +10 more
TL;DR: These studies indicate that monocytopoiesis is controlled by a circuitry involving sequentially miRNA 17-5p–20a–106a, AML1 and M-CSFR, whereby miRNAs function as a master gene complex interlinked withAML1 in a mutual negative feedback loop.
Journal ArticleDOI
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1
Ruggero De Maria,Ruggero De Maria,Ann Zeuner,Ann Zeuner,Adriana Eramo,Cristina Domenichelli,Désirée Bonci,Francesco Grignani,Francesco Grignani,Srinivasa M. Srinivasula,Emad S. Alnemri,Ugo Testa,Cesare Peschle,Cesare Peschle +13 more
TL;DR: It is shown that immature erythroid cells express several death receptors whose ligands are produced by mature erythroblasts, and caspase-mediated cleavage of GATA-1 may represent an important negative control mechanism in erythropoiesis.
Journal Article
Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha.
Francesca Aloisi,Alessandra Carè,Giovanna Borsellino,Paolo Gallo,Silvia Rosa,Anna Bassani,Andrea Cabibbo,Ugo Testa,Giulio Levi,Cesare Peschle +9 more
TL;DR: The capacity of human astrocytes to synthesize and release cytokines active on hemolymphopoietic cells supports the concept that these cells play an important role in the regulation of inflammatory and immune responses in a variety of brain pathologies.
Journal ArticleDOI
Arsenic Trioxide as an Inducer of Apoptosis and Loss of PML/RARα Protein in Acute Promyelocytic Leukemia Cells
Wenlin Shao,Mirco Fanelli,Felicetto Ferrara,R. Riccioni,Angelika Rosenauer,Kelly Davison,William W. Lamph,Samuel Waxman,P. G. Pelicci,F Lo Coco,Giuseppe Avvisati,Ugo Testa,Cesare Peschle,Carlo Gambacorti-Passerini,Clara Nervi,Wilson H. Miller +15 more
TL;DR: The molecular basis of these differences in the effects of As2O3 and retinoic acid may guide the clinical use of arsenic compounds and provide insights into the management of leukemias that do not respond to retinic acid.