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Danielle Gregor
Researcher at Rutgers University
Publications - 12
Citations - 352
Danielle Gregor is an academic researcher from Rutgers University. The author has contributed to research in topics: Hyperalgesia & Elevated plus maze. The author has an hindex of 11, co-authored 12 publications receiving 262 citations.
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Journal ArticleDOI
Ethanol Withdrawal Drives Anxiety-Related Behaviors by Reducing M-type Potassium Channel Activity in the Lateral Habenula
Seungwoo Kang,Jing Li,Wanhong Zuo,Rao Fu,Danielle Gregor,Krešimir Krnjević,Alex Bekker,Jiang-Hong Ye +7 more
TL;DR: In rats at 24 h withdrawal from systemic ethanol administration, the basal firing rate and the excitability of LHb neurons in brain slices was higher, whereas the amplitude of medium afterhyperpolarization and M-type K+ currents were smaller, when compared to ethanol naive rats.
Journal ArticleDOI
Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depressive-like behavior and alcohol intake in rats.
Jing Li,Seungwoo Kang,Rao Fu,Liangzhi Wu,Wei Wu,Hongwei Liu,Danielle Gregor,Wanhong Zuo,Alex Bekker,Jiang-Hong Ye +9 more
TL;DR: Results demonstrate that CaMKII‐AMPAR signaling in the LHb exemplifies a molecular basis for depressive‐like symptoms during ethanol withdrawal and that inhibition of this signaling pathway may offer a new therapeutic approach to address the comorbidity of alcohol abuse and depression.
Journal Article
Chronic intermittent voluntary alcohol drinking induces hyperalgesia in Sprague-Dawley rats.
TL;DR: The results suggest that utilizing the SD rat under the IA2BC procedure could be a useful animal model with heuristic value for exploring the mechanisms underlying hyperalgesia induced by chronic alcohol abuse.
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Downregulation of M-channels in lateral habenula mediates hyperalgesia during alcohol withdrawal in rats.
Seungwoo Kang,Seungwoo Kang,Jing Li,Wanhong Zuo,Pei Chen,Danielle Gregor,Rao Fu,Xiao Han,Alex Bekker,Jiang-Hong Ye +9 more
TL;DR: Data reveal a central role for the LHb in hyperalgesia during alcohol withdrawal, which may be due in part to the suppression of M-channels and highlights M- channels in the LHB as a potential therapeutic target for hyperalGESia in alcoholics.
Journal ArticleDOI
Dysfunction in amygdala-prefrontal plasticity and extinction-resistant avoidance: A model for anxiety disorder vulnerability.
Jennifer E. Fragale,Veronika Khariv,Danielle Gregor,Ian M. Smith,Xilu Jiao,Stella Elkabes,Richard J. Servatius,Kevin C.H. Pang,Kevin D. Beck +8 more
TL;DR: Dysfunction in amygdala-PFC plasticity is innate in anxiety vulnerable rats and may promote extinction-resistant avoidance by disrupting communication between the amygdala and prefrontal cortex.