Joëlle Chabry

TL;DR: Affinity labeling and binding experiments showed that the 110-kDa NT3 receptor can be partly transformed into a higher affinity by cotransfection with furin, which is the first transmembrane neuropeptide receptor that does not belong to the superfamily of G-protein-coupled receptors.

TL;DR: Evidence is provided that the sequence specificity of PrP-res formation in this model is determined more by the conversion to protease resistance than by the initial binding step, and that after the initialbinding, further intermolecular interactions are required to complete the process of conversion to the protease-resistant state.

TL;DR: Investigation of immune-to-brain communication in mice by examining the effects of peripheral LPS injection on neuroinflammation encompassing cytokine and chemokine production, microglia and central nervous system (CNS)-associated phagocyte activation, immune cell infiltration and serotonergic neuronal function suggests a possible link with depressive disorders.

TL;DR: It is reported that copper stimulates the endocytosis of PrP-sen via a caveolin-dependent pathway in both microglia and neuroblastoma cells and it is demonstrated that filipin is a potent inhibitor ofPrP-res formation into chronically infected neuro Blastoma cells.

TL;DR: In vivo recruitment of microglial cells soon after intraocular injection of scrapie-infected cell homogenate (hgtsc+) is investigated using immunohistochemistry on retinal sections and shows that the microglia migration is at least partly under the control of chemokine receptor-5 (CCR-5) activation.