D
Darin Dobler
Researcher at University of Essex
Publications - 6
Citations - 786
Darin Dobler is an academic researcher from University of Essex. The author has contributed to research in topics: Methylglyoxal & Glycation. The author has an hindex of 5, co-authored 5 publications receiving 719 citations.
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Journal ArticleDOI
Peptide Mapping Identifies Hotspot Site of Modification in Human Serum Albumin by Methylglyoxal Involved in Ligand Binding and Esterase Activity
TL;DR: Methylglyoxal modification of critical arginine residues, whether experimental or physiological, is expected to disrupt protein-ligand interactions and inactivate enzyme activity by hydroimidazolone formation.
Journal ArticleDOI
Increased Dicarbonyl Metabolism in Endothelial Cells in Hyperglycemia Induces Anoikis and Impairs Angiogenesis by RGD and GFOGER Motif Modification
TL;DR: It is shown that increased modification of vascular basement membrane type IV collagen by methylglyoxal, a dicarbonyl glycating agent with increased formation in hyperglycemia, caused endothelial cell detachment, anoikis, and inhibition of angiogenesis, and likely contributes to similar vascular dysfunction in diabetes.
Journal ArticleDOI
Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes
Beatriz Duran-Jimenez,Darin Dobler,Sarah Moffatt,Naila Rabbani,Charles H. Streuli,Paul J. Thornalley,David R. Tomlinson,Natalie J. Gardiner +7 more
TL;DR: Early glycation and AGE residue content of endoneurial ECM proteins increase markedly in STZ-induced diabetes, which may provide a mechanism for the failure of collateral sprouting and axonal regeneration in diabetic neuropathy.
Journal ArticleDOI
Reversal of hyperglycemia-induced angiogenesis deficit of human endothelial cells by overexpression of glyoxalase 1 in vitro.
Usman Ahmed,Usman Ahmed,Darin Dobler,Sarah Larkin,Sarah Larkin,Naila Rabbani,Naila Rabbani,Paul J. Thornalley,Paul J. Thornalley +8 more
TL;DR: It is concluded that increased protection against dicarbonyl glycation of endothelial cell protein protects hyperglycemia‐induced angiogenesis deficit.