D
Darryl D. Dixon
Researcher at Bristol-Myers Squibb
Publications - 33
Citations - 2425
Darryl D. Dixon is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Catalysis & Nucleophile. The author has an hindex of 16, co-authored 32 publications receiving 2045 citations. Previous affiliations of Darryl D. Dixon include University of Hawaii & University of Hawaii at Manoa.
Papers
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Journal ArticleDOI
Practical and innate carbon–hydrogen functionalization of heterocycles
Yuta Fujiwara,Janice A. Dixon,Fionn O’Hara,Erik Daa Funder,Darryl D. Dixon,Rodrigo A. Rodriguez,Ryan D. Baxter,Bart Herlé,Neal W. Sach,Neal W. Sach,Michael R. Collins,Michael R. Collins,Yoshihiro Ishihara,Phil S. Baran +13 more
TL;DR: It is reported that zinc sulphinate salts can be used to transfer alkyl radicals to heterocycles, allowing for the mild, operationally simple formation of medicinally relevant C–C bonds while reacting in a complementary fashion to other innate C–H functionalization methods.
Journal ArticleDOI
A New Reagent for Direct Difluoromethylation
Yuta Fujiwara,Janice A. Dixon,Rodrigo A. Rodriguez,Ryan D. Baxter,Darryl D. Dixon,Michael R. Collins,Donna G. Blackmond,Phil S. Baran +7 more
TL;DR: This mild, operationally simple, chemoselective, and scalable difluoromethylation method is compatible with a range of nitrogen-containing heteroarene substrates of varying complexity as well as select classes of conjugated π-systems and thiols.
Journal ArticleDOI
A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.
Eli M. Wallace,James P. Rizzi,Guangzhou Han,Paul M. Wehn,Zhaodan Cao,Xinlin Du,Tzuling Cheng,Robert M. Czerwinski,Darryl D. Dixon,Barry Goggin,Jonas Grina,Megan M. Halfmann,Melissa A. Maddie,Sarah R. Olive,Stephen T. Schlachter,Huiling Tan,Bin Wang,Keshi Wang,Shanhai Xie,Rui Xu,Hanbiao Yang,John A. Josey +21 more
TL;DR: PT2385 represents a novel class of therapeutics for the treatment of RCC with potent preclincal efficacy as well as improved tolerability relative to current agents that target the VEGF pathway.
Journal ArticleDOI
Redox-Active Esters in Fe-Catalyzed C–C Coupling
Fumihiko Toriyama,Josep Cornella,Laurin Wimmer,Tie-Gen Chen,Darryl D. Dixon,Gardner S. Creech,Phil S. Baran +6 more
TL;DR: The first couplings of redox-active esters with organozinc and organomagnesium species using an Fe-based catalyst system originally developed for alkyl halides are demonstrated, and this new C–C coupling is scalable and sustainable.
Journal ArticleDOI
Practical radical cyclizations with arylboronic acids and trifluoroborates.
TL;DR: Practical radical cyclizations take place in water, open to air, and in a scalable fashion employing catalytic silver nitrate and stoichiometric potassium persulfate, illustrating the utility of these mild conditions for the generation of polycyclic scaffolds.