Darya Burakov

TL;DR: The purification of a complex of at least 10 VDR interacting proteins (DRIPs) ranging from 65 to 250 kD that associate with the receptor in a strictly 1,25-dihydroxyvitamin D3-dependent manner are described, demonstrating the existence of a new complex of novel functional nuclear receptor coactivators.

TL;DR: It is suggested that DRIP150 and DRIP205 functionally link GR AF‐1 and AF‐2, and represent important mediators of GR transcriptional enhancement.

TL;DR: The in vivo recruitment of other endogenous DRIP subunits to ER in response to estradiol treatment in MCF-7 cells is demonstrated and a cyclic association and dissociation of coactivators with the promoter is observed, suggesting an exchange between these coactivator complexes at the target promoter.

TL;DR: Evidence is presented that a fragment of DRIP205 containing only its receptor interacting region acts to selectively inhibit ER's ability to activate transcription in response to estradiol, suggesting a key role for the DRIP coactivator complex in estrogen-ER signaling.

TL;DR: The findings indicate that the IFN-activated ISGF3 transcription factor regulates transcription through contact with DRIP150 and implicate the Mediator coactivator complex in IFn-activated gene regulation.