D
Dave Davis
Researcher at University of Kentucky
Publications - 2
Citations - 3517
Dave Davis is an academic researcher from University of Kentucky. The author has contributed to research in topics: Calcium in biology & Kainate receptor. The author has an hindex of 2, co-authored 2 publications receiving 3446 citations.
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Journal ArticleDOI
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
Peter Seubert,Carmen Vigo-Pelfrey,Frederick Esch,Michael K. Lee,Harry F. Dovey,Dave Davis,Sukanto Sinha,Michael Schiossmacher,Justine Whaley,Cathy Swindlehurst,Robert T. McCormack,Robert L. Wolfert,Dennis J. Selkoe,Ivan Lieberburg,Dale Schenk +14 more
TL;DR: It is demonstrated that Aβ is produced and released both in vivo and in vitro, and new opportunities for developing diagnostic tests for Alzheimer's disease and therapeutic strategies aimed at reducing the cerebral deposition of Aβ are offered.
Journal ArticleDOI
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
TL;DR: The hypothesis that beta-amyloid can destabilize neuronal calcium regulation and render neurons more vulnerable to environmental stimuli that elevate intracellular calcium levels is tested.