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David A. Borkholder
Researcher at Rochester Institute of Technology
Publications - 108
Citations - 2425
David A. Borkholder is an academic researcher from Rochester Institute of Technology. The author has contributed to research in topics: Nucleic acid & Pulse wave velocity. The author has an hindex of 22, co-authored 104 publications receiving 2237 citations. Previous affiliations of David A. Borkholder include University of Rochester & Stanford University.
Papers
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Journal ArticleDOI
Development and application of cell-based biosensors.
TL;DR: Network of excitable cells cultured on microelectrode arrays are uniquely poised to provide rapid, functional classification of an analyte and ultimately constitute a potentially effective cell-based biosensor technology.
Patent
Method for quantitative analysis of a nucleic acid amplification reaction
TL;DR: In this article, the Fourier Transform based algorithm is used to quantitatively measure the initial amount of a target nucleic acid in a sample which has been subjected to in vitro nucleic acids amplification to produce data that is analyzed by using a Fourier transform based algorithm.
Journal ArticleDOI
Plasma-etched neural probes
David T. Kewley,Matthew D. Hills,David A. Borkholder,I.E. Opris,Nadim I. Maluf,C.W. Storment,James M. Bower,Gregory T. A. Kovacs +7 more
TL;DR: In this paper, a new method is presented for microfabricating silicon-based neural probes that are designed for neurobiology research, which provide unique capabilities to record high-resolution signals simultaneously from multiple, precisely defined locations within neural tissue.
Journal ArticleDOI
Portable cell-based biosensor system for toxin detection
Joseph J. Pancrazio,Paul P. Bey,David S. Cuttino,Julian K. Kusel,David A. Borkholder,Kara M. Shaffer,Gregory T. A. Kovacs,David A. Stenger +7 more
TL;DR: A portable cell-based biosensor has been developed and characterized that relies on extracellular recording from excitable cells cultured over an array of platinized gold microelectrodes and incorporates a feedback control system for temperature regulation and a 36-channel multiplexer for selection of up to four output channels for simultaneous display.